最新结核病总论英文课件PPT.ppt

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1、结核病总论英文tuberculosisfactoroftuberculosisincidencerising：HIVspread.TBstrainoccurdrugresistance.fluidpopulationincreasing.ManagementTBpatientnotperfect、preventionandcurenotefficiency.Poverty、populationincreasing.2etiologyMycobacterium、Acidfastness、G+、aerobe。Growthtorpidity,cultureneed4-6weeks.Typing:

2、humantype、bovinetype、Birdtype、mousetype、mainhumantype。wayofinfection：respirationtract、digestivetrack、skinorplacenta.3pathogenesyIF-reinforcementCD+8、NKcellsactivitytophagocytosisTB.meanwhiletoleadhistoclasiadelayedallergy:Tcellmedia，macrophagetobeeffectorcell，tokillreinfectionTBandcausecheesynecro

3、sisorholeformationAfterInfectionTB:primarydisease（5%），Secondarydisease（5%）,nottofallillalllive(90%)7diagnoseObjectivetodiscoverfocal。Definitediseasecharacter、sizewhetherornotdeliverbacterium。8diagnose1historyTBtoxicsymptomtocontactTBpatientBCGvaccinationacuteinfection:measles，pertussisSupersensiti

4、vityerythemanodosum、exanthematousconjunctivitis。9diagnose2：OTtestagent：1/2000or1/10000PPDdose：0.1ML（OT5U）（or1U）。position：leftforearmpalmarisbelow1/3Infuseintracutaneousform6-10mmhillock。48~72hrobservationreaction。10diagnosisreaction<5mm(-)≧5mm(+)10-19mm(++)≧20mm(+++)Superreaction:induration、vesic、

5、localulceration(++++)。11diagnosissignificancepositivereactionAfterBCGvaccinationOlderchildrenpositivereactionindicatetobeeverinfectedwithTBbefore。InfantneverBCGvaccinationindicatenewinfectionrecent。StrongpositivereactionindicatethereisactivenessTB.。from（-）to（+）、from<10mmto>10mm,orincrease>6mmbyact

6、ivenessTB.。12diagnosisnegativereactionneverinfectionTBfirstInfectTBduring4-8weeksfalsenegativereaction，immunefunctiontobepresseddown。WrongwithtestorPPDineffective13diagnosisBCGVaccinationandnaturalinfectionpositivereactioncondition14diagnosis3：laboratoryexamination（1）findTBspecimen：sputum、gastricj

7、uice、C.S.F、serouscavityliquid.method：smear、fluorescentstaining、BACTECsystem：culturefor2weeks，testmycobacteriametabolismproduction，todistinguishTBandatypical.mycobacteria.Ltuberclebacterium：mutationTB，form、constru