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1、盐酸帕罗西汀治疗脑卒中后抑郁的疗效分析作者：毛向莹单位：长垣县人民医院神经内科，河南长垣453400【摘要】目的观察盐酸帕罗两汀对脑卒中后抑佃(PSD)的疗效。方法60例PSD患者随机分为治疗组和对照纽，每组30例。对照纽给了脑血管病當规治疗，治疗纽在常规治疗基础上给予盐酸帕罗西汀，每日1次，每次20mg•d-l,晨起口服。2纽疗程均为8周。治疗前、治疗第8周行汉密尔顿抑郁最表(HAMD)评分,并评定其疗效和不良反应。结果治疗纽•痊愈10例，显著进步8例，进步9例，无效3例，有效率90%；对照组显著进步5例，进步7例，无效18例，有效率40%,2组比较有
2、显著性差异(χ2=17.526,P<0.05),且治疗纽不良反应明显少于对照纽(χ2=：23.64,P<0.05)o结论盐酸帕罗西汀能较好地改善脑卒中后的抑郁情绪,是治疗PSD的理想药物之一。【关键词】帕罗西汀脑卒中抑郁EffectofparoxetinehydrochlorideonpatientswithpoststrokedepressionMAOXiangyingDepartmentofNeurology,thePeople′sHospitalofChangyuanCounty,Changyuan453400,Chi
3、naAbstract:ObjectiveTostudythecurativeeffectsofparoxetinehydrochlorideonthetreatmentofpoststrokedepression(PSD).MethodsSixtypatientswithPSDwererandomlydividedintotreatmentgroup(n=30)andcontrogroup(n=30).Controlgroupwasgivenroutinetreatmentforcerebrovasculardisease,andthetreatmentgroup
4、werereceivedparoxetinehydrochloridetreatment,20mgperdayorallyatdaybreakexceptforcommontreatment.Thecourseoftreatmentwas8weekstorbothgroups.BetoretreatmentandattheSthweekoftreatment,theclinicaleffectsandadversereactionwereassessedwiththeHamiltondepressionscale(HAMD).ResultsIntreatmentg
5、roup,tencasewererecovery,eightcasesweresignificantadvancement,ninecaseswereprogressandinefficiencywastwocases,theeffectivepowerwas90%.Incontrolgroup,fivecasewererecovery,significantadvancementwassevenandinefficiencywaseighteencases,theeffectivepowerwas40%.Therewassignificantdifference
6、betweenthetreatmentgroup(90%)andthecontrogroup(40%)(χ2=17.526,P<0.05).Incidenceoftheadverseeffectswaslowerintreatmentgroupthanthatincontrolgroup(P<0.05).ConclusionParoxetinehydrochloridemaysignificantlyimprovePSDandwillbecomeoneofidealdurgsinthetreatmentofPSD.Keywords:paroxe
7、tine;stroke;depression脑卒中后抑郁(poslstrokedepression,PSD)是脑卒中常见的并发症之一，据国内文献报道,PSD发生率为20%〜75%,表现为情绪低落，自责自罪，兴趣减低,对疾病的恢复失去信心，抑郁状态能延长疾病的恢复，降低患者的生活质量，増加病死率［1］。为此，对PSD患者早期一药物干预是完全有必耍的，对患者康复也是有益的。作者采用盐酸帕罗西汀对PSD患者进行治疗，取得较好疗效。现报道如下。1资料与方法L1一-般资料选择2005年2月至2007年11月在长垣具人民医院神经内科门诊及住院治疗的60例PSD患者，随机将其分
8、为对照组与
