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时间:2020-04-02
《萎胃康颗粒逆转慢性萎缩性胃炎的p53机制研究_程艳.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、辽宁中医杂志2013年第40卷第10期·2155·萎胃康颗粒逆转慢性萎缩性胃炎的p53机制研究12程艳,赵岩(1.滨州市人民医院,山东滨州256603;2.滨州医学院,山东烟台264003)摘要:目的:探讨萎胃康颗粒逆转慢性萎缩性胃炎(CAG)的机制。方法:将90只SD大鼠随机抽取18只为正常对照组(正常组),其余72只采用多重刺激6周复制大鼠CAG模型。确定造模成功的64只随机分为4组,即模型对照组、萎胃康大剂量组、萎胃康小剂量组、三九胃泰组,分别ig生理盐水、萎胃康高浓度水煎液、萎胃康低浓度水煎液和三九胃泰混悬液,1次/d。给药30d后,观察对大鼠胃黏膜
2、组织形态及突变型p53表达的影响。结果:模型组大鼠胃黏膜病理无明显改善,突变型p53表达较正常组显著升高(P<0.01);各治疗药物均可显著改善胃黏膜萎缩,降低胃黏膜突变型p53表达,较模型组具有显著性差异(P<0.01)。其中以萎胃康大剂量组大鼠胃黏膜p53的平均光密度最低,较其他治疗组有显著性差异(P<0.01)。结论:萎胃康能改善和逆转实验性萎缩性胃炎大鼠胃黏膜萎缩,其疗效与剂量有关,其机制可能与抑制细胞的异常增殖有关。关键词:萎胃康;萎缩性胃炎;p53中图分类号:R573.32文献标志码:B文章编号:1000-1719(2013)10-2155-02
3、Researchonp53MechanismofWeiweikangReversingChronicAtrophicGastritis12CHENGYan,ZHAOYan(1.BinzhouPeople'sHospital,Binzhou256603,Shandong,China;2.BinzhouMedicalUniversity,Yantai264003,Shandong,China)Abstract:Objective:TodiscussthemechanismofWeiweikangreversingchronicatrophicgastritis.
4、Methods:18ratsfrom70SDratswererandomlyselectedoutasnormalcontrolgroup(normalgroup).Theremaining72ratsweremadeCAGmodelwiththemultiplestimulationsfor6weeks.Theremaining64ratswhichweremodeledsuccessfullywererandomlydividedintofourgroupssuchasmodelgroup,Weiweikanglargedosegroup,Weiweik
5、angsmalldosegroupandSanjiuWeitaigroup.Thegroupswereinjected0.9%saline,Weiweikanghighpotencydecoction,WeiweikanglowpotencydecoctionandSanjiuWeitaisuspension,onceaday.After30days,thegastricmucosapathologicalchangesandtheexpressionofmutantp53wereobserved.Results:Therewasnosignificantd
6、ifferentiationofgastricmucosapathematologyinmodelgroup.Theexpressionofmutantp53madeasignificantincreasecomparedwithmodelgroup(P<0.01).Thetherapeuticdrugsallcouldsignificantlyimprovegastricmucosaatrophyandreducetheexpressionofthemutantp53andcomparedwiththemodelgrouptherewasobviousdi
7、fference(P<0.01).Theaverageopticaldensityofmutantp53inWeiweikanglargedosegroupwasminimum,withsignificantdifferencecomparedtotheotherther-apeuticgroups(P<0.01).Conclusion:Weiweikangcanimproveandreversethegastricatrophyofexperimentalatrophicgastritisofrats,whichrelatedtodose.Itsmecha
8、nismmayberelatedwithrestra
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