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《偏钒酸钠对大鼠神经行为功能的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、预防医学情报杂志2012年5月第28卷第5期JPreyMedInf,May.2012,Vo1.28,No.5385【论著】偏钒酸钠对大鼠神经行为功能的影响崔鹂,周鼎伦,兰亚佳[摘要]目的研究偏钒酸钠对大鼠的协调能力和记忆力的影响。方法采用重复测量方差分析偏钒酸钠对大鼠协调能力和记忆力的影响。结果①染毒后,高、低剂量组大鼠出现腹泻或鼻炎症状,每组各有2只死亡,且实验后期体重较对照组为轻。②转棒实验,3组大鼠在棒上停留的时间表现为染毒后明显下降,染毒停止后持续上升的趋势,在30d时点上转棒时间由低到高依次为高剂量组、对照组、低剂量照组,差异有统计学意义(P
2、<0.05)。③水迷宫实验,3组大鼠到达终点的时间存在波动且差异无统计学意义(P>0.05)。错误次数的分析发现高、低剂量组大鼠均存在错误次数基线水平低,染毒后增加,停止染毒后减少的时间趋势,对照组大鼠的错误次数在各时点轻微波动;30d时点上错误次数从从高到低依次为高剂量组、低剂量组、对照组,差异有统计学意义(P<0.05)。结论偏钒酸钠对大鼠的协调能力有损害作用,对大鼠的记忆力可能有损害作用。[关键词]偏钒酸钠;记忆力;协调能力;重复测量方差分析;水迷宫实验;转棒实验[中图分类号]R135.1[文献标识码]A[文章编号]1006—4028(2012)
3、05—0385—03NeurobehavioralOutcomesOfVanadiumExposureInRatsCUI—Li,ZHOUDing—lun,LANYa—jiaWestChinaSchoolofPublicHealth,SichuanUniversity,Chengdu610041,SichuanProvince,China.AbstractObjectiveToexploretheefectofvanadiumoncoordinationandmemoryofrats.MethodRats’neu—robehavioraloutcomes
4、ofvanadiumexposurewereanalyzedbyMANOVAofrepeatedmeasuringdata.Results(~)Afterpoisoning,diarrheaorrhinitisoccurredinhighandlowdosegroup,with2deathineachgroup.Theweightofratsinthelatestageofexperimentwaslighterthancontro1.②InRotarodexperiment,residenttimeinthebarpresentedthatdecre
5、asedsignificantlyafterexposure,andcontinuedtoriseafterthecessationofexpo—sure,Theturningtimewashighestinlowdosegroup,followedbycontrolgroupandhighdosegroup,withthedifferencesstatisticallysignificant(P<0.05).③InMazeexperiment,thetimethatratsspenttotheendwith3groupsfluctuated,with
6、nostatisticaldiference(P>0.05).Inthefalsenumbersanalysis,thenumberoferrorsexistinhighandlowdosegroupwereinlowbaselinelevels,presentedthetrendthatincreasedafterex—posure,reducedafterthecessationofexposure,Thenumberoferrorsincontrolratsfluctuatedlightlyateachtimepointfluctuations.
7、Thenumberoferorsin30dtimepointwashighestinfhighdosegroup,followedbylowdosegroupandthecontrolgroup,withthediferencesstatisticallysignificant(P8、ry;coordination;MANOVAofrepeatedmeasuring;Mazee
8、ry;coordination;MANOVAofrepeatedmeasuring;Mazee
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