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时间:2020-05-24
《甲胎蛋白异质体(AFP—L3)对肝癌切除术后复发的预测价值探讨.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·3128·2013年第34卷第2l期JournalofOiqiharUniversityofMedicine.2013.Vo1.34.No.21.论著.甲胎蛋白异质体(AFP—L3)对肝癌切除术后复发的预测价值探讨黄海深周永均何兰香李宇鸣唐光定陈国强【摘要】目的探讨甲胎蛋白异质体(AFP-L3)对原发性肝癌(primarylivercancer,PLC)患者肝癌切除术后肿瘤复发转移的预测价值。方法选择2008年6月至2009年l2月期间在我院接受首次肝癌切除术的48例PLC患者,同步测定患者术前、术后血清AFP和AFP—L3含量,计算AFP.13占总AFP
2、的百分比(以AFP.I3%≥10%作为阳性判断标准)。并对患者进行长期复查和随访,以了解血清AFP和AFP.L3对PLC患者肝癌切除术后肿瘤复发转移的预后判断价值。结果48例PLC患者在随访期间共有25例发生肿瘤复发转移,随访1、2、3年的总体复发率分别为22.9%(11/48)、39.6%(19/48)、52.1%(25/48)。患者术前血清AFP.IJ3%与总AFP水平之间无相关性;术前、术后血清AFP—L3%与肿瘤复发转移之问均呈正相关,而术前、术后血清AFP水平与肿瘤复发之间缺乏明确的相关性。结论血清AFP.L3%与肝癌切除术后肿瘤复发有关联,对PL
3、C患者术后复发转移的判断有重要临床价值。【关键词】甲胎蛋白异质体;原发性肝癌;肿瘤复发;预测价值ExplorethevalueofAFP-L3inserumforpredictingrecurrenceofprimarylivercancerafterhepatectomy^—shen,eta1.eClinicallaboratory,PeopleSHospitalofYangshanCounty,Qingyuan,Guangdong.513100.inn【Abstract】ObjectiveTodiscussthevalueofAFP—I3inscramf
4、orpredictingrecurrenceandtransferofPLCpost-operative.MethodsT0ta11y48patients,withprimarylivercancer(PLC),receivedsurgicalresectionfromJuly2008toDecember2009wereenrolledinthepresentstudy.Thedetailedclinicaldatawereobtainedforeachpatient.Pre—andpost—operativeAFPandAFP—L3levelsinseru
5、mweremeasuredcontinuously.andtheproportionsofAFP—L3werecalculated(withcut—ofvalue≥10%forAFP一13iSpositive).Thepatternsoftheirpost.operativechangeswerefollowedupforalong—termperiod.Results25casesoccuredtumorrecurrenceduringthefollow.upperiodin48patientswithPLC.Therecurenceratesofthep
6、atientsduringthefirst3yearswere22.9%(11/48),39.6%(19/48),52.1%(25/48)respectively.TherewasnorelativerelationshipbetweenserumAFPandAFP—L3levelbeforeoperation.Thepre—andpost—operationserumAFP一13levelwassignificantlycorelatedwithtumorrecurrence.buttherelationbetweenpre—andpost—operati
7、onserumAFP]evelandtumorrecurrencewasnotclearyet.ConclusiOIlSSerumAFP—L3leveliSassociatedwithPICrecurrenceandthereforevaluableforpredictingPLCrecurrence.【Keywords】Alpha-fetoprotein—L3;Primarylivercancer;Neoplasmsrecurence;Predictivevalue原发性肝癌(primarylivercancer,PLC)是全球第五大最率㈨。近年来的应用研
8、究表明,甲胎蛋白异质体(AFP—IJ3)主常见的恶性
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