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时间:2020-05-15
《普罗帕酮联合胺碘酮治疗老年急性心肌梗死合并AF的临床分析.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、IIl12lIIl国处方药第13卷第6期·论著·普罗帕酮联合胺碘酮治疗老年急性心肌梗死合并AF的临床分析严华芳,黄秀英,蔡金芳(上海市浦东医院急诊科,上海201300)【摘要】目的探讨普罗帕酮联合胺碘酮治疗老年急性心肌梗死(AMI)合并心房颤动(AF)的疗效及不良反应。方法选取2008年1月~2014年3月收治的AMI合并有AF的老年患者96例,随机分成对照组和试验组,每组48例。对照组患者应用胺碘酮治疗,试验组患者采用普罗帕酮联合胺碘酮治疗。分析比较两组患者接受治疗后心房颤动转复效果、窦性心律维持率及不良反应情况。结果0
2、~6h及6~12h内试验组患者AF转复率高于对照组(x=6.400、8.491,P<0.05),18~24h内对照组高于试验组(x:5.897,P0.05)。试验组窦性心律维持有效率明显高于对照组,差异具有统计学意义(x。=20.364,P<0.05)。试验组不良反应率低于对照组(x=7.940,P3、合用药TreatmentofelderlypatientswithAMIandAFbyPropafenoneandAmiodaroneandanalysistheeficacyandadversereactions】ⅣHua-fang。HUANGXiu-ying,CAIJin-fang.Departmentofemergency,ShanghaiPudongHospital,Shanghai201300,China.【Abstract】ObjectiveToexplorethetreatmentofelderlypatie4、ntswithacutemyocardialinfection(AMI)andatrialfibrillation(AF)bypropafenoneandamiodaroneandanalysisiteficacyandadversereactions.MethodsNinetysixelderlypatientswithAMImergerwithAFinourhospitalfromJanuary2008toMarch2014werecollectedandrandomlydividedintocontrolandexp5、erimentalgroups,eachgroupof48.Thecontrolgroupweretreatedwithamiodm'oneandtheexperimentalgroupweretreatedwithpropafenoneandamiodarone.Cardioversionofatrialfibrillation,sinusrhythmmaintenancerateandadversereactionsofthetwogroupswereanalyzedandeomp~edaftertreatment.R6、esultsTheAFcardioversionrateofexperimentalgroupwassignificantlyhigherthanthatofcontrolgroupin0~6hand6~12h(x=6.400、8.491,P<0.05),controlgroupwassignificantlyhigherthanthetreatmentgroupin18~24h(x=5.897,P<0.05),Therewerenostatisticaldiferencesinthecardioversionrateof7、12~18handtotal(x=2.987、1.200,P>0.05).Sinusrhythmmaintenancerateofexperimentalgroupwassignificantlyhigherthancontrolgroup(x20.364,P<0.05).Adversereactionratesoftheexperimentalgroupwassignificantlylowerthanthecontrolgroup(x=7.940,P<0.05).ConclusionTreatmentofAMIandA8、Fbypropafenoneandamiodaronearemoresuperiorandsafetythanamiodaronealone,isworthinonpromotingtheapplicationclinically.【Keywords】Propafenone;Amiodarone;Acu
3、合用药TreatmentofelderlypatientswithAMIandAFbyPropafenoneandAmiodaroneandanalysistheeficacyandadversereactions】ⅣHua-fang。HUANGXiu-ying,CAIJin-fang.Departmentofemergency,ShanghaiPudongHospital,Shanghai201300,China.【Abstract】ObjectiveToexplorethetreatmentofelderlypatie
4、ntswithacutemyocardialinfection(AMI)andatrialfibrillation(AF)bypropafenoneandamiodaroneandanalysisiteficacyandadversereactions.MethodsNinetysixelderlypatientswithAMImergerwithAFinourhospitalfromJanuary2008toMarch2014werecollectedandrandomlydividedintocontrolandexp
5、erimentalgroups,eachgroupof48.Thecontrolgroupweretreatedwithamiodm'oneandtheexperimentalgroupweretreatedwithpropafenoneandamiodarone.Cardioversionofatrialfibrillation,sinusrhythmmaintenancerateandadversereactionsofthetwogroupswereanalyzedandeomp~edaftertreatment.R
6、esultsTheAFcardioversionrateofexperimentalgroupwassignificantlyhigherthanthatofcontrolgroupin0~6hand6~12h(x=6.400、8.491,P<0.05),controlgroupwassignificantlyhigherthanthetreatmentgroupin18~24h(x=5.897,P<0.05),Therewerenostatisticaldiferencesinthecardioversionrateof
7、12~18handtotal(x=2.987、1.200,P>0.05).Sinusrhythmmaintenancerateofexperimentalgroupwassignificantlyhigherthancontrolgroup(x20.364,P<0.05).Adversereactionratesoftheexperimentalgroupwassignificantlylowerthanthecontrolgroup(x=7.940,P<0.05).ConclusionTreatmentofAMIandA
8、Fbypropafenoneandamiodaronearemoresuperiorandsafetythanamiodaronealone,isworthinonpromotingtheapplicationclinically.【Keywords】Propafenone;Amiodarone;Acu
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