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时间:2020-04-21
《重组人血管内皮抑制素联合顺铂胸腔灌注治疗乳腺癌恶性胸腔积液的临床观察.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、广西医学2014年8月第36卷第8期1025重组人血管内皮抑制素联合顺铂胸腔灌注治疗乳腺癌恶性胸腔积液的临床观察▲周文献谢伟敏陆永奎刘燕谭爱花王洪学农丽贾昱娴(广西医科大学附属肿瘤医院化疗五科,南宁市530021,E—mail:zwx33058@163.com)【摘要】目的观察重组人血管内皮抑制素联合顺铂胸腔灌注治疗乳腺癌恶性胸腔积液的疗效和安全性。方法乳腺癌伴恶性胸腔积液患者36例,通过胸腔置入中心静脉导管,充分引流胸腔积液后,胸腔内依次注入生理盐水+重组人血管内皮抑制素,生理盐水+顺铂,生理盐水+地塞米松注射液;重组人血管内皮抑制素每周给药2次,共3周;顺铂及地塞米
2、松注射液仅第1周给药2次。结果36例患者中,胸腔积液完全缓解26例(72.2%),部分缓解5例(13.9%),稳定4例(11.1%),进展1例(2.8%),总有效31例(86.1%);出现轻度胸膜粘连、肥厚、分隔6例(16.7%);生活质量改善29例(80.6%),生活质量稳定6例(16.7%),生活质量下降l例(2.8%);不良反应主要为恶心、呕吐、胸痛、发热、中性粒细胞减少,发生率较低,均为1—2级。结论重组人血管内皮抑制素联合顺铂胸腔灌注治疗乳腺癌恶性胸腔积液疗效肯定,不良反应轻,安全性高。【关键词】乳腺癌;恶性胸腔积液;重组人血管内皮抑制素;顺铂;药物疗法【中图
3、分类号】R737.9【文献标识码】A【文章编号】0253—4304(2014)08-1025-03DoI:10.11675/j.issn.0253—4304.2014.08.01ObservationonCavityInfusionTherapywitllRecombinantHumanEndostatinCombinedwithCisplatinforBreastCancerPatientswithMafignantPleuralEfusionZHOUWen—xian,XIEWei—min,LUYong—kui,LIUYan,TANAi-hua,WANGttong一姗
4、,NONGLi,JIAYu—xian(No.5DepartmentofChemotherapy,AfiliatedTumorHospitalofGuangxiMedicalUniversity,Nanning530021,China)【Abstract】ObjectiveToobservetheefectandsafetyofthecavityinfusiontherapywithrecombinanthumanendostatin(Endostar)combinedtllcisplatinforbreastcancerwithmalignantpleuralefusi
5、on.MethodsTheadequatedrainageofpleuralefusionWasperformedin36breastcancerpatients’vitllmalignantpleuralefusionbypleuralcentralvenol/scatheterimplantation.Andthensaline+Endostar,saline+cisplatin,saline+dexamethasonewereinjectedintothepleuralcavitysequentially.EndostarWasadministeredtwicea
6、weekforthreeweeks,whilecisplatinanddexamethasonewereusedonlytwiceaweekinthefirstweek.ResultsOfthese36patients,CRofclinicalevaluationWasobservedin26patients(72.2%),PR5patients(13.9%),SD4patients(11.1%),PD1patient(2.8%)andRR31patients(86.1%).Therewere6patients(16.7%)hadmildpleuraladhesions
7、,thickeningandseparation.Twenty—ninepatients(80.6%)gainedanimprovementoflifequality,6patients(16.7%)maintainedstabilityand1patient(2.8%)acquiredlowerlifequality.Theadversereactionswerenausea,vomiting,chestpain,fever,neutropenia,withalowincidenceofgradeI一11.ConclusionTheca
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