蝶豆根改善链脲霉素诱导的糖尿病模型大鼠认知减退-论文.pdf

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1、中西医结合学报2012年8月第10卷第8期JournalofChineseIntegrativeMedicine，August2012，Vo1．10，No．8·939·Clitoreaternatea，aherbfr0mIndianfolklore，improvesstrept0z0t0cin-induceddiabetesanddiabetes-inducedcognitivedeclineinratsarunaA．Talpate，UmaA．Bhosale：。，MandarR．Zambar~Depart

2、mentofPharmacology，SinhgadCollegeofPharmacy，Vadgaon，Pune411041，Maharashtra，IndiaDepartmentofPharmacology，Smt．KashibaiNavaleMedicalCollegeandGeneralHospita1，Narhe，Pune411041，Maharashtra，IndiaoBJECTIVE：Tostudytheantidiabetjc，neurochemicaI-antioxidantandcogn

3、itionprotectiveeffectsofC'litoreatematealeavesonaratmodelofdiabeticcognjtivedecliRe．METHoDS：AntjdiabeticactivilYwaseva『uatedbyserum(】lucoseandbodyweiqhtestimationinethanolextractofClitoreaternatea(EECT)一treateddiabeticrats．EffectsofEECTonspalia1workinamem

4、OrV(SWM)andspatialreferencememory(SRM)wereevaluatedbyY—mazeandMorriswatermazetestsrespectivelY．Neurochemica『一antioxidanteffectsofEECTwerestudiedbyacetylchoIjnesteraseassay．andmeasurementsofthjobarbituricacjdreactivesubstances(TBARSs)，superoxidedismutase(S

5、OD)andcatalase(CAT)IeveIsindiabeticrats．RESULTS：The200and400mr／kqofEECTshowedasiqnificantantidiabeticactivilybydecreasingserumqIucoseleveI(PdO．05，P

6、uiqdtocausesianificantincreasesinSWMandSRMinretentiontrialsonY—mazeandMorriswatermazerespeclively(P％0．05，P<0．01)．SiqicantdecreaseslnacetyIcho¨nesteraseactivityandTBARSlevel。andsiqnificantinoreaseInCATlevelwereobservedinratstreatedwilh200and400ma／k．qofEECT

7、comparedwithratsinthediabeticcontrolarouP(P

8、Re。andwarrantstheneedforfurtherstudjestoeIucidateitsmodeofaction．KEYWORDS：diabetesmellitus；hypOglycemicagents；plants，medicinal；neurobehavioramanifestations；rats，Sprague-DawleyD0I：10．3736／jcim20120816JournalofChinese