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时间:2020-04-16
《结直肠癌中L-选择素表达及其与淋巴转移的关系-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·610·临床与实验病理学杂志JClinExpPathol2014Jun;30(6)网络出版时间:2014—6—2014:03网络出版地址:http://www.cnki.net/kcms/doi/10.13315/j.cnki.cjcep.2014.06.005.html结直肠癌中L一选择素表达及其与淋巴转移的关系李坤’,徐坤勇,刘博,林媛媛,武欣,金春亭摘要:目的探讨L一选择素(L—selectin)在结直肠癌组织中的表达及其与结直肠癌淋巴转移的关系。方法采用免疫组化Pv9000两步法检测104例结直肠癌组织、55例正常结直肠黏膜组织中L.s
2、electin的表达。应用流式细胞术(floweytometry,FCM)定量检测45例结直肠癌组织和17例正常结直肠黏膜组织中L-selectin的含量。结果结直肠癌组织中L.selectin阳性率及表达量均明显高于癌旁正常黏膜组(P<0.05);有淋巴转移组明显高于无转移组(P<0.05);TNM分期中Ⅲ+Ⅳ期组明显高于I+Ⅱ期组(P<0.05)。结论L—seleetin在结直肠癌中的表达与结直肠癌的发生、TNM分期、淋巴结转移有关,其可能参与结直肠癌发生及淋巴结转移过程。关键词:结直肠肿瘤;L一选择素;淋巴结转移;免疫组织化学;流式细胞术中
3、图分类号:R735.34文献标志码:A文章编号:1001—7399(2014)06—0610—04doi:10.13315/j.cnkicjcep.2014.06.005ExpressionofL-selectinincolorectalcarcinomaanditsrelationwithlymphaticmetastasisLIKun,XUKun-yong,LIUBo,LINYuan-yuan,WUXin,JINChun—ting(DepartmentofPathology,theFirstAffiliatedHospitalofHebeiN
4、orthUniversity,Zhangfiakou075000,China;DpartmentofPar—macy,thefHospitalZhangfiakouCity,Zhangfiakou075000,China;DepartmentofPathology,HebeiNorthUniversity,Zhangfiakou075000,China)Abstract:PurposeToinvestigatetheexpressionofadhesionmoleculeL-selectininhumancolorectalcarcinoma,a
5、ndtoanalyzetheircorrelationwithlymphnodemetastasis.MethodsTheexpressionofL—selectinwasdetectedbyimmunohistochemicalmethodin104casesofcoloreetalcarcinomaand55casesofnormalintestinalmucosaadjacenttocarcinoma.Flowcytometry(FCM)wasusedtoquanti~thecontentsofL—selectinin45casesofco
6、lorectalcarcinomaand17casesnormalintestinalmucosa.ResultsThepositiverateandquantifiedexpressionofL—selectininthecolorectalcarcinomagroupweresignificantlyhigherthanthatinadjacentmucosagroup(P<0.05).Theexpressioninthetumorwithlymphnodemetastasiswassignificantlyhigherthanthatint
7、hetissuewithoutlymphnodemetastasis(P<0.05).AsforTNMstage,theexpressioninstageIII+1VgroupwassignificantlyhigherthanthatinstageI+Ⅱgroup(P<0.05).ConclusionsTheexpressionofL—selectiniscloselyassociatedwithdevelopment,TNMstageandmetas—tasisofeoloreetalcarcinoma.Itmayparticipateint
8、hecarcinogenesisandlymphnodemetastasisofcolorectalcarcinoma.Keywords
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