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时间:2020-04-23
《VEGFR-3和podoplanin在结直肠癌中的表达及淋巴管生成和转移中的作用-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、全科医学临床与教育2014年7月第12卷第4期ClinicalEducationofGeneralPracticeJu1.2014,Vo1.12,No.4.367.著·VEGFR一3$1:lpodoplanin在结直肠癌中的表达及淋巴管生成和转移中的作用于欢赖登攀徐立群任晓华f摘要】目的观察血管内皮生长因子受体3(VEGFR一3)及‘肾小球足突细胞膜黏蛋白(podoplanin)在结直肠癌组织中的表达.探讨VEGFR一37Lpodoplanin在结直肠癌淋巴管生成及转移中的作用。方法应用免疫组织
2、化学法检测52例结直肠癌组织、20例大肠息肉组织和2O例正常对照组织中VEGFR一32Lpodoplanin的表达.分析其与结直肠癌患者的临床病理参数的相关性。结果VEGFR一3主要表达在结直肠癌细胞胞膜及胞质中,阳性表达率67_30%,明显高于在大肠息肉组织和正常大肠组织中的阳性表达率(x分别=6.75、16.77,P均<0.05);其在小淋巴管内皮的阳性表达率仅为9.61%。podoplanin主要表达在癌细胞淋巴管内皮细胞上,podoplanin标记的淋巴管密度(LMVD)明显高于大肠息肉
3、组织和正常大肠组织(分别=3.15、3.54,P均4、FR-3andpodoplaninincolorectalcarcinomaandtheroleinlymphangiogenesisandlymphaticmetastasisYUHuan,LAIDengpan,XULiqun,eta1.DepartmentofEmergency,AfiliatedHospitalofHangzhouNormalUniversity,Hangzhou310015,China【Abstract】ObjectiveToobservetheexpressionofV5、EGFR-3andpodoplaninincolorectalcarcinomaandinvestigatetheroleofvascularendothelialgrowthfactorreceptor3(VEGFR-3)andpodoplanininlymphangi0genesisandlymphaticmetastasisofcolorectalcarcinoma.MethodsTheexpressionofVEGFR一3andpodoplanininspecimensof52color6、ectalcarcinoma.20colorectalpolypstissuesand20colorectalnormaltissuesweredetectedbyimmunohistochemistry.AndtherelationshipsbetweenVEGFR一3,podoplaninandclinicopathologicalfeaturesofcolorectalcarcinomawereanalyzed.ResultsVEGFR一3wasmainlyexpressedineolor7、ectalcarcinomacellmembraneandcytoplasm,thepositiveratewere67.30%whichweresignificantlyhigherthanthoseofthecolorectalpolypstissuesandthenormalboweltissues(x=6.75,16.77,P<0.05).Itwasmarginallyexpressedinthesmalllymphaticendothelium,thepositiveratewas9.8、61%.podoplaninwasmainlyexpressedinlymphaticendothelialcells.Thelymphaticvesseldensity(LMVD)markedbypodoplaninofcolorectalcarcinomaweresignificantlyhigherthanthoseofthecolorectalpolypstissuesandthenormalbow-eltissues(t=3.15,3.54,P<0.05).Theexpressiono
4、FR-3andpodoplaninincolorectalcarcinomaandtheroleinlymphangiogenesisandlymphaticmetastasisYUHuan,LAIDengpan,XULiqun,eta1.DepartmentofEmergency,AfiliatedHospitalofHangzhouNormalUniversity,Hangzhou310015,China【Abstract】ObjectiveToobservetheexpressionofV
5、EGFR-3andpodoplaninincolorectalcarcinomaandinvestigatetheroleofvascularendothelialgrowthfactorreceptor3(VEGFR-3)andpodoplanininlymphangi0genesisandlymphaticmetastasisofcolorectalcarcinoma.MethodsTheexpressionofVEGFR一3andpodoplanininspecimensof52color
6、ectalcarcinoma.20colorectalpolypstissuesand20colorectalnormaltissuesweredetectedbyimmunohistochemistry.AndtherelationshipsbetweenVEGFR一3,podoplaninandclinicopathologicalfeaturesofcolorectalcarcinomawereanalyzed.ResultsVEGFR一3wasmainlyexpressedineolor
7、ectalcarcinomacellmembraneandcytoplasm,thepositiveratewere67.30%whichweresignificantlyhigherthanthoseofthecolorectalpolypstissuesandthenormalboweltissues(x=6.75,16.77,P<0.05).Itwasmarginallyexpressedinthesmalllymphaticendothelium,thepositiveratewas9.
8、61%.podoplaninwasmainlyexpressedinlymphaticendothelialcells.Thelymphaticvesseldensity(LMVD)markedbypodoplaninofcolorectalcarcinomaweresignificantlyhigherthanthoseofthecolorectalpolypstissuesandthenormalbow-eltissues(t=3.15,3.54,P<0.05).Theexpressiono
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