CT结直肠癌总病灶糖酵解与淋巴结转移及淋巴管生成的关系-论文.pdf

《CT结直肠癌总病灶糖酵解与淋巴结转移及淋巴管生成的关系-论文.pdf》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。

1、·1382·中国医学影像技术2014年第3O卷第9期ChinJMedImagingTechnol，2014，Vol30，No9·◆．腹部影像学CorrelationoftotallesionglycolysisOilF—FDGPET／CTimageswithlymphaticmetastasisandlymphangiogenesisincolorectalcarcinomaTIANMo—han，yULi-juan，QINYu，WANGDa—long，WANGXin。LIYing—ci(CentralofPET／CT-MRI，HarbinMedicalUniv

2、ersityCancerHospital，Harbin150081，China)[Abstract]ObjectiveToexplorecorrelationoftotallesionglycolysis(TLG)withlymphaticvesseldensity(LVD)andexpressionleve1ofvascularendothelialgrowthfactor—C(VEGF-C)incolorectalcancer(CRC)．MethodsRetrospectiveanalysisof36patientswithCRC(19caseswithl

3、ymphaticmetastasis，17caseswithoutlymphaticmetastasis)provedbypathologyandunderwentPET／CTexaminationbeforesurgicaloperation．Themaximumstandardizeduptakevalue(SUV⋯)andTIGwererecorded．ImmunohistochemistrywasusedtoanalyzetheexpressionofVEGF-Coftumortissueandthenormalmueosa1tissue．D2—40w

4、asusedtomarkthe1ymphaticendothelia1cells，LVDwasrecorded。andtheircor—relationwithSUVandTLGwereanalyzed．ResultsPositiveexpressionofglucosetransporterprotein1(GLUT一1)andVEGF-Cintumortissuewereremarkablyhigherthanthoseofnormalmucosaltissue(allP<0．01)．Statisticallysignifi—cantdifferences

5、ofSUV⋯，TLG，LVDandVEGF-Cwerefoundbetweenlymphaticmetastaticandnon-lymphaticmeta—staticpatients(SUV⋯：￡一3．602，P一0．001；TLG：一3．421，P一0．002；LVD：一3．051，P：0．004；VEGF-C：一8．047，P一0．045)．Intumortissue，therewere1inearcorrelationbetweenSUVandTLG，TLGandLVD，TLGandin—tegralopticaldensity(IOD)ofGLUT

6、一1(r一0．607，0．654，0．367，allP

7、ogenesisandlymphaticmetastasisinCRCinsomedegree．[Keywords]Colorectalneoplasms；Tomography，emission—computed，single—photon；Totallesionglycolysis；VascularendothelialgrowthfactorC：NeoplasmmetastasisF—FDGPET／CT结直肠癌总病灶糖酵解与淋巴结转移及淋巴管生成的关系田墨涵，于丽娟，秦誉，王大龙，王欣，李迎辞(哈尔滨医科大学附属肿瘤医院PET／CT-MRI中心，黑龙江哈尔

8、滨150081)[摘要]目的探索结直肠