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1、中国组织工程研究与临床康复第11卷第48期2007-12-02出版JournalofClinicalRehabilitativeTissueEngineeringResearchDecember2,2007Vol.11,No.48CRTERReview★StructuralmodificationandapplicationofchitosanZhangMin,RenHui-xiaAbstractInstituteofBiochemicalandBACKGROUND:Chitosan,derivedfromchitin,hasapoorsolubilitywhichlim
2、itsitsapplicationgreatly.ForimprovingitsBiotechnologicaldissolubility,accordingtothefeaturethatintramolecularhydroxyandaminogroupinchitosanareeasytobechemicallyDrug,SchoolofPharmacy,modified,andfunctionalgroupsareintroducedtoimproveitssolubilityandfunctionalitytowidentherangeofitsShandong
3、University,application,whichhasbecomeoneofthenewtrendofdevelopmentforinvestigatingtheapplicationofchitosan.Ji'nan250012,ShandongProvince,ChinaOBJECTIVE:Tosumuptheresearchadvancementsintheapplicationandmodificationofchitosanincarboxylation,acylation,alkylation,etherification,etc.ZhangMin★,
4、Studyingformaster'sdegree,InstituteofRETRIEVESTRATEGY:TherelevantarticlespublishedinEnglishbetween1998and2007weresearchedforinPubmedBiochemicalanddatabasewiththekeywordsof"chitosan,modification",andtherelevantarticlespublishedbetween1998and2007wereBiotechnologicalsearchedforinElsevierScie
5、ncedatabasewiththekeywords"chitosan,modification"andsearch"derivate"withinsearchDrug,SchoolofPharmacy,resultsinEnglish.Articlescloselyrelatedtothestructuralmodificationandapplicationofchitosanwereinvolved,andShandongUniversity,repetitiveandoldstudieswereexcluded.Ji'nan250012,ShandongProvi
6、nce,ChinaLITERATUREEVALUATION:Totally154articleswereselected,and30ofthemareaccordedwiththeinclusivecriteria,zhangmin_034@163.including5arereviews,andtheothersareclinicalorexperimentalstudies.comCorrespondenceto:DATASYNTHESIS:Theintramolecularhydroxyandaminogroupsinchitosanaremostlymodifie
7、dbecausetheyareRenHui-xia,easytobechemicallymodified.Recently,reportslayparticularemphasisonthemodificationincarboxylation,acylation,Associateprofessor,Instituteofalkylation,etherification,etc.Functionalgroupsareintroducedtoimproveitssolubilityandfunctionalitytowide
