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1、JournalofNeuroimmunology,20(1988)111-116111ElsevierJNI00700Coronavirus-inducedCNSdisease"amodelforvirus-induceddemyelinationMichaelJ.Buchmeier1,RobertG.Dalziel2andMarckJ.M.Koolen31ScrippsClinicandResearchFoundation,LaJolla,CA92037,U.S.A.,2Royal(Dick)Schoolo
2、fVeterinaryStudies,Edinburgh,U.K.,and3NetherlandsBloodtransfusionService,Amsterdam,TheNetherlands(Received26July1988)(Accepted27July1988)Keywords:Coronavirus;Demyelination,virus-induced;CentralnervoussystemdiseaseIntroductionwhichseparatetheself-limitingben
3、igninfection,whichoccursinmostindividuals,fromthelethalAlthoughvirusesofferanattractiveexplanationdiseasearepoorlyunderstood.fortheetiologyofsomeformsofchronicprogres-Therearecircumstantialdatatosupportthesivecentralnervoussystem(CNS)diseasesinman,suggestio
4、nthatvirusescausehumandemyelinat-etiologyhasonlybeenproveninahandfulofingdisease.Norrbyandcoworkers(Norrby,1978)cases.Amongthem,subacutesclerosingpanen-describedoligoclonalIgGspecificformeaslesandcephalitis(SSPE)isararelatecomplicationofothercommonhumanviru
5、sesinthecerebrospinalchildhoodmeaslescharacterizedbyalongtimefluidofMSpatients.MeaslesvirusandthecloselyspanbetweentheinitialattackandtheonsetofrelatedparamyxoviruscaninedistemperhavebeenSSPE.Thislatentorsilentphasemaybeadecadeimplicatedbyepidemiologicalstu
6、diesshowinganorlonger,andtheinteractionbetweenvirusandassociationofantibodiestotheseviruseswithMShostduringthisintervalispoorlyunderstood(TerbutinsufficientevidenceisavailabletoestablishaMeulenandHall,1978).Progressivemultifocalcausallink.Itispreciselythese
7、difficultiesinleukoencephalopathy(PML)isanothervirus-in-establishingacausalrelationshipbetweenvirusesducedchronicprogressivediseaseoftheCNSandMSthathasledusandotherstofocuson(Weineretal.,1972).Inthiscase,theinfectiouswell-establishedanimalmodelsofCNSdisease
8、agentisaDNA-containingpapovavirus.Infection(Lampertetal.,1973;Weiner,1973;SturmanandwiththePMLagentiscommonbutprogressiontoHolmes,1982;StroopandBaringer,1982;Koolenthefatalchronicgraymatterdiseaseisrar
