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1、CliniealAllergy,i988.Volume18.pages119-129InfluenceofatopyontheclinicalmanifestationsofcoronavirusinfectioninadultvolunteersKATHEEENA.CALLOW,D.A.J.TYRRELL.RJSHAW*,PENNYEITZHARRIS*,A.J.WARDLAW*atidA.B.KAY*MRCComtmmColdUnit.HarvardHospital.Salisbury,IVilt.shireand*CardiothoracicInst
2、itute,BromptonHospital,Lottdon.U.K,(Rt'ceirt'dinoriginatJorm22ApritI9H7LIIHIinreri.tcdJormI'J.AugustNH7:acceptedJorpuhtication8SeptemberI9H71SummaryInanattempttounderstandtherelationshipbetweenviralupperrespiratorytractinfectionandtheunderlyingvirologicalandimmunologicalmechanisms
3、,thirty-fourvolunteerswereinoculatedintranasallywithcoronavirus229E;subsequentvirussheddingand/orantibodyrises,indicatingactiveinfection,wereobservedintwenty-nine.Therewasagreaterincreaseinindependentlymeasuredscoresofclinicalseverity,e.g.coldsymptoms,inthosewithdetectableIgEinnas
4、alsecretions(/'<00I).AsimilarassociationwasfoundbetweenclinicalscoresandserumIgEconcentrations^150IU/ml,buttherelationshipwithsystemicatopy,asassessedbyskin-prickteststocommonallergens,waslessmarked.Amoredetailedstudyoftwelveoftheinfectedvoiunlcersfailedtoexpiainthesefindingsonthe
5、basisofmastceilmediatorrelease,asconcentrationsofleukotrieneB4.thesulphidopeptideleukotrieneC4,andhistamine,werenotappreciablyelevatedinthenasaisecretionsfollowingvirusinoculation.Similarly,therewasnoevidencethatcircuiatingcoronavirusspecificIgEwasproduced.Thus,thisstudysuggeststh
6、atatopymayberelatedlotheseverityofcoldsymptomsproducedbycoronavirus229E.althoughtheexactconnectionhasyettobedetermined.IntroductionInallergicsubjects,particularlyasthmatics,exacerbationscommonlyoccurduringrespiratoryvirusinfectionssuggestingthepossibleinvolvementofIgE[1].Thereisli
7、ttleexperimentalevidencetoconfirmtherelationshipbetweensymptomsofviralinfectionandatopy,despitethereadyavailabilityofmeasuresofatopy,suchasCorrespondence:KathleenA.Callow,MRCCommonColdUnJUHarvardHospital,CoombeRoad.Salisbury,Wiilshire,U.K.119120KathleenA.Callowetal.reactionstoskin
8、-pricktestingandcirculatingIgEcon
