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1、糖耐量减低患者胰岛素抵抗与血脂变化的临床观察[摘要]目的探讨糖耐量减低(IGT)患者胰岛索抵抗和血脂的相关性。方法选择2011年1月〜2013年1月来本院下属5家社康就诊的120例IGT患者作为实验组,选取同时期120例糖耐量正常志愿者作为对照组,分别测定两组入选者空腹胰岛索(Fins)水平、餐后2h胰岛索(2hlns)水平、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、游离脂肪酸(FFA)等各项指标水平,并计算两组入选者胰岛素抵抗指数(H0MA-TR).胰岛素分泌指数(HOMA-B)以及葡萄糖处置指
2、数(GDI)等。结果实验组TG、FFA.空腹血糖均显著高于对照组,IIDL-C明显低于对照组,差异均有统计学意义(P0.05);实验组HOMA-IR、Fins、2hIns水平显著高于对照组,GDI显著低于对照组,差异均有统计学意义(P<0.05)o结论IGT患者有明显的胰岛素抵抗以及高血脂症状,因此临床中要注意防止出现高脂血症。[关键词]糖耐量减低;胰岛索抵抗;血脂[中图分类号]R587[文献标识码]B[文章编号]1674-4721(2013)11(c)-0187-02Clinicalobservationofinsulinresistanceandbloo
3、dlipidchangesinpatientswithimpairedglucosetoleranceCIIENYong-qingDepartmentofGeneralPractice,PeoplezsHospitalofYantianDistrictinShenzhenCityinGuangdongProvince,Shenzhen518081,China[Abstract]ObjectiveToexplorethecorrelationbetweeninsulinresistanceandblood1ipidinpatientswithimpairedg
4、lucosetolerance(IGT).Methods120patientswithIGTtreatedin5communityhea1thservicecentersaffiliatedtoourhospitalfromJanuary2011toJanuary2013wereselectedasexperimentalgroup.Another120volunteerswithnormalglucosetoleranceinthesameperiodwerechosenascontrolgroup.Theindexes1ikefastinginsulin
5、(FTns)level,2hpostprandialinsulin(2hIns)level,triglyceride(TG),totalcholesterol(TC),highdensitylipoproteincholesterol(HDL-C),lowdensitylipoproteincholesterol(LDL-C)andfreefattyacid(FFA)weretestedinbothgroupsinordertocalculatethehomeostasismodelassessmentofinsulinresistance(HOMA-TR)
6、,homeostasismodelassessmentofBcellsecretion(HOMA-13)andglucosedisposalindex(GDI)•ResultsThelevelsofTG,FFA,andfastingblood-glucoseintheexperimentalgroupwereremarkablyhigherthanthoseofthecontrolgroup,whilethevalueofHDL-Cwasobviouslylowerthanthatofthecontrolgroupwithstatisticaldiffere
7、nces(P0.05)・ThelevelsofHOMA-IR,Finsand2hInsintheexperimentalgroupwereobservablyhigherthanthoseofthecontrolgroup,buttheGDTwas1owerthanthatofthecontrolgroup,thedifferenceswerestatisticallysignificanl(P〈0.05)・ConclusionDuetoobviousinsulinresistanceandhyperlipidemiainpatientswithIGT,th
8、epreventionofitsoccurrence