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1、论文-血清胱抑素C检测对肝硬化患者肾功能损害的诊断价值毕业设计报告(论文)课题名称专业学号学生姓名指导教师起论:口期工作地点血清胱抑索c检测对肝硬化患者肾功能损害的诊断价值摘要FI的通过检测肝硬化患者血清胱抑素C(CysC)的水平,探讨血清CysC在肝硬化患考早期肾功能损害屮的诊断价值及意义。方法采川免疫比浊法检测118例肝硬化、48例CHB患者及30例健康对照组血清CysC、B2微球蛋白(B2-MG)水平,同时采用酶法测定血清肌Kf(Scr)>尿素(Urea)水平。对各组血清CysScr>Urea及P2~MG水平差异、和关性及异常率进行比较分析。结果肝硕化组、CHB组和对照组的血清Cys
2、C水平分别为(1.29土0・33)mg/L、(0.98±0.21)mg/L和(0.92±0.15)mg/L,肝硬化组显著高于CHB组(P<0.001)和对照组(P<0.001)o肝硬化组Scr、Urea和B2-MG水平分别为(69.22+21.21)Pmol/L、(5.47±2.16)mmol/L和(2.58±0.88)mg/L,均显著高于对照组(P均v0.001)。各组血清CysC与Scr均呈止相关,肝硕化组(r二0.502,P<0.001),CIIB组(—0.485,P<0.001),对照组(1-0.494,P<0.01)o肝硬化组血清CysC异常率(75.4%)显著高于Scr(5.9
3、%)、Urea(17.8)%和P2-MG(22%),(P均V0.001)。结论血清CysC可以作为评价肝硬化早期肾功能损害的标志物,为临床相关疾病的诊断提供参考依据。关键词:胱抑素C;肌酎;尿索;B2微球蛋白;肝硕化abstractObjectiveToexplorethediagnosticvalueandsignificaneeofCystatinC(CysC)serumlevelintheevaluationofrenalfuntioninpatientswithlivercirrhosis.MethodsSerumCysCandB2microglobulin(B2-MG)level
4、sweredetectedbyimmunoturbidimetricassayin118patientswith1ivercirrhosis,48patientswithChronichepatitisB(CHB)and30healthygroupasControl,whileSerumcreatinine(Scr)andUreaweremeasuredusingenzymaticmethod.Furthermore,ThedifferencesofserumCysC,Scr,Urea,02-MGlevelsandtheirrelationshipsbetweengroupswereana
5、lyzed.ResuItsTheserumCysC1evelswere(1.29±0.33)mg/L(Livercirrhosisgroup),(0.98±0.21)mg/L(CHBgroup)and(0.92±0.15)mg/L(Controlgroup)respectively,LivercirrhosisgroupwassignificantlyhigherthanCIIBgroup(P<0.001)andControlgroup(P<0.001).TheScr,UreaandP2-MG1evelsinliver第1页共6页cirrhosisgroupwere(69.22±21.21
6、)umol/L,(5.47±2.16)mmol/Land(2.58±0.88)mg/Lrespectively,andalsoweresignificantlyhigherthanthatinControlgroup(P<0.001).TherewassignificantlypositivecorrelationbetweenserumCysCandScrlevels(livercirrhosisgroup:r=0.502,P<0.001.CHBgroup:r=0.485,P<0.001andControlgroup:r=0.494,P<0.01).TheabnormalrateofCy
7、sC(75.4%)inlivercirrhosisgroupwassignificantlyelevatedthanScr(5.9%),Urea(17.8%)and32-MG(22%),(P<0.001).ConclusionsSerumCysCcanbeusedasanmarkerforevaluatingearlyrenaldamageinpatientswithlivercirrhosis,andprovidere