放射治疗与89Sr核素治疗对椎骨转移癌性疼痛的临床疗效对比研究

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1、放射治疗与89Sr核素治疗对椎骨转移癌性疼痛的临床疗效对比研究任振泰；李甸源；崔静；谢新立；常伟2(450052郑州，郑州大学第一附属医院：放疗科'核医学科彳)［摘要］目的比较放射治疗与核素治疗对椎骨转移癌疼痛的临床疗效。方法回顾分析我院2005年1月至2010年5刀期间治疗的椎骨转移癌疼痛患者143例，其中放疗组115例，根据单次剂量不同分为常规分割、中分割、低分割三组，吟厂核素治疗组28例。对放疗组Z间、放疗组Ai89Sr治疗组Z间的疼痛缓解有效率、起效时间进行比较。结果常规分割、中分割、低分割3组疼痛缓解有效率分别为90.63%(29/32例)、84.21%(32/

2、38例)、80.00%(36/45例)，放疗总体疼痛缓解有效率84.35%(97/115例),89Sr核素治疗疼痛缓解有效率78.57%(22/28例)。不同放疗剂最组间、放疗组与8°Sr核素治疗组间疼痛缓解有-效率无统计学差异(P>0.05)。常规分制、中分割、低分制和89Sr缓解疼痛的起效时间分别为(14.21±2.51)、(7.78±2.96)、(2.83±1.56)、(9.27±2.88)d。结论放射治疗与的Si•核素治疗对缓解椎体的骨转移性疼痛疗效相当，低分割放疗疼痛缓解的起效时间最短，常规分割起效时间最长。［关键词］放疗;89锂(89Sr)；椎骨转移癌；疼痛C

3、omparisonofpalliatingspinebonepainwithradiotherapyand89SrRENZhentaiLIDianyuan1,CUIJing2,XIEXinli2,CHANGWei2(DepartmentofRadiotherapy,DepartmentofNuclearMedicine.ThefirstAffiliatedHospital,ZhengzhouUniversity,Zhengzhou450052,China)［Abstract］ObjectiveTheclinicalvalueofradiotherapyand89Srinr

4、elievingofspinebonepainwascompared.MethodsFromJanuary2005toMay2010,143patientswereacquired.115patientsundergoneradiotherapywhileother28patientsweretreatedwith"'Si;Threeradiotherapyfractionswasconventionalfractiongroup,middlefractiongroupandhypofiactiongroup.Analyzethepainreliefratesofdiff

5、erentmethodsand.ResultsTheremissionratesofspinebonepainwere84.35%(97/115cases)ingroupradiotherapyand78.57%(22/28cases)ingroup“Sr.Theeffectivesofdifferentradiotherapyfractionsasfollows：conventionalfractiongroupwas90.65%(29/32cases),middlefractiongroupwas84.21%(97/115cases),andhypofractiong

6、roupwas80.00%(36/45cases).TherewerenosignificantdifferencetorelievepainbetweenradiotherapyandS9Sr(P>0.05),andamongthreegroups(P>0.05).Thepainonsettimewas：conventionalfraction14.21±2.51d,middlefraction7.78±2.96d,hypofraction2.83±1.56dand89Sr9.27±2.88d.ConclusionsBothradiotherapyand89Srwere

7、remarkableeffectivetreatmentforspinebonepain.Thesideaffectstorelievebonepainbetweenthesetwogroups,andamongthreefractionsgroupswasrare.Hypofiactionradiotherapywasthefirstonetoreliefspinebonepainwhileconventionalfractionradiotherapywasthelastone.［Keywords］Radiotherapy