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《口服特比萘芬加外用益康唑短程联合疗法治疗足癣的临床对照研究【临床医学专业论文设计】》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、临床医学论文•口服特比荼芬加外用益康哩短程联合疗法治疗足癣的临床对照硏究作者：杨斌，杨琴，晏洪波，吴宁，余君贤，李曾三【摘要】目的评价口服特比蔡芬片加外用益康口坐乳膏短程联合疗法治疗足癣的疗效和安全性。方法采用随机数字表法将124名患者分为两组：试验组予特比蔡芬片250mg口服，1次/d，联合益康口坐乳膏外用，2次/d，共7d；对照组予益康畔乳膏外用，2次/d，同时口服维生素C片0.1gH次/d，共28d。于停药时和停药后4周时观察临床疗效和真菌学疗效停药后4周时观察复发情况。结果共有113例患者完成临床观察，脫落7例（试验组1例，对照
2、组6例），剔除4例（对照组4例）。停药时两组相比试验组治愈率明显低于对照组（X2=23.03，P<0・01），有效率及真菌清除率差异无统计学意义（无2=0.33，P〉0・05；力2=0.03，P〉0.05）；停药后4周时两组相比试验组治愈率、有效率及真菌清除率均显著高于对照组（无2=17.21，P<0.01；无2=14.56，P<0.01；%2=23.03，P<0.01）；停药后4周时两组相比试验组复发率明显低于对照组（刀2=14.04，P<0.01）；两组不良反应发生率相比差异无统计学意义5=3.71，P>0.05）。结论口服特比蔡芬
3、片加外用益康哩乳膏短程联合疗法治疗足癣依从性和安全性高、疗效好。【关键词】足癣；特比荼芬；联合疗法Abstract:ObjectiveTostudytheefficacyandsafetyofshortoraladministrationofterbinafinecombinedwithtopicalapplicationofcconazolcinthetreatmentoftincapedis・McthodsAnopenlabelled,randomized,controlledandparalleiclinicaltrialwasc
4、arriedout.Atotalof124patientswithclinicalandmycologicaldiagnosisoftineapedisweredividedintotwogroups.Thetrialgroupwastreatedwithoralterbinafine250mgdaily,and1%ofeconazoleointmenttwicedaily,continuouslyfor7days.Thecontrolgroupwastreatedwith1%ofeconazoleointmenttwicedailya
5、ndoralvitamineC(asplacebo)0.1gdai1y.Efficacyandsafetywerecompared.ResultsAttheendoftreatment,theclinicalcurerateofthetrialgroupwassignificantly1owerthanthatofthecontrolgroup(%2=23.03,P<0.01),andtherewerenosignificantdifferencesineffectiverateandmycologicalclearanceratebe
6、tweenthetwogroups(x2=0.33,P>0.05;%2二0.03,P>0.05)・Foutweekslateraftertheendoftreatment,theclinicalcurerate,theeffectiverateandthemycologicalclearancerateofthetrialgroupweresignificantlyhigherthanthatofthecontrolgroup(X2=17.21,P<0.01;%2=14.56,P<0・01;x2=23.03,P<0・01),andthe
7、recurrenceratewassignificantly1owerthanthatofthecontrolgroup(x2=14.04,P<0.01).Theincidenceofadverseeventsinthetrialgroupwasnotsignificantlydifferentfromthatinthecontrolgroup.ConclusionShorttermoraladministrationofterbinafinecombinedwithtopicalapplicationofeconazoleissafe
8、,welltoleratedandeffectiveinthetreatmentoftineapedis・Keywords：tineapedis;terbinafine;combinedtherapy足癣是
