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1、毕业设计报告(论文)课题名称血清胱抑素C检测对肝硬化患者肾功能损害的诊断价值专业学号学生姓名指导教师起讫日期工作地点血清胱抑素C检测对肝硬化患者肾功能损害的诊断价值摘要目的通过检测肝硬化患者血清胱抑素C(CysC)的水平,探讨血清CysC在肝硬化患者早期肾功能损害中的诊断价值及意义。方法采用免疫比浊法检测118例肝硬化、48例CHB患者及30例健康对照纽.血清CysC、[32微球蛋白(32-MG)水平,同时采用酶法测定血清肌酊(Scr)s床索(Urea)水平。对各纟II.血清CysC、Scr、Urea及B2・MG水平差界、相关性及界常率进行比较分析。结果肝
2、硬化组、CHB组和対照组的血清CysC水平分别为(1.29±0.33)mg/L^(0.98±0.21)mg/L和(0.92±0.15)mg/L,肝硬化组显著高于CHB组(PV0.001)和对照组(PV0.001)。肝硬化组Scr、Urea和P2-MG水平分别为(69.22±21.21)umol/L、(5.47±2.16)mmol/L和(2.58±0.88)mg/L,均显著高于对照组(P均<0.001)。各纽血清CysC与Scr均呈正相关,川:硬化组(r=0.502,P<0.001),CHB组(r=0.485,P<0.001),对照组(r=0.494,PV0
3、.01)。肝硬化组血清CysC异常率(75.4%)显著高于Scr(5.9%)、Urea(17.8)%和B2-MG(22%),(P均V0.001)。结论血清CysC可以作为评价肝便化早期肾功能损害的标志物,为临床相关疾病的诊断提供参考依据。关键词:胱抑素C;肌酎;尿素;B2微球蛋白;肝硬化abstractObjectiveToexplorethediagnosticvalueandsignificanceofCystatinC(CysC)serumlevelintheevaluationofrenalfuntioninpatientswithlivercir
4、rhosis.MethodsSerumCysCandp2microglobulin(p2-MG)levelsweredetectedbyimmunoturbidimetricassayin118patientswithlivercirrhosis,48patientswithChronichepatitisB(CHB)and30healthygroupasControl,whileSerumcreatinine(Scr)andUreaweremeasuredusingenzymaticmethod.Furthermore,Thedifferencesofs
5、erumCysC,Scr,Urea,卩2・MGlevelsandtheirrelationshipsbetweengroupswereanalyzed.ResultsTheserumCysClevelswere(1.29±0.33)mg/L(Livercirrhosisgroup),(0.98±0.21)mg/L(CHBgroup)and(0.92±0.15)mg/L(Controlgroup)respectively,LivercirrhosisgroupwassignificantlyhigherthanCHBgroup(P<0.001)andCont
6、rolgroup(P<0.001).TheScr,Ureaand卩2・MGlevelsinlivercirrhosisgroupwere(69.22土21.21)pmol/L,(5.47±2.16)mmol/Land(2.58±0.88)mg/Lrespectively,andalsoweresignificantlyhigherthanthatinControlgroup(P<0.001).TherewassignificantlypositivecorrelationbetweenserumCysCandScrlevels(livercirrhosis
7、group:r=0.502,P<0.001.CHBgroup:r=0.485,P<0.001andControlgroup:r=0.494,P<0.01).TheabnormalrateofCysC(75.4%)inlivercirrhosisgroupwassignificantlyelevatedthanScr(5.9%),Urea(17.8%)andp2-MG(22%),(P<0.001).ConclusionsSemmCysCcanbeusedasanmarkerforevaluatingearlyrenaldamageinpatientswith
8、livercirrhosis,andprovidereferenc