5.35 Stem Cell Therapy Facility Design

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1、5.35StemCellTherapyFacilityDesignJLiu,DLv,YXu,LSong,YLiu,andPLiu,TheFirstAffiliatedHospitalofDalianMedicalUniversity,Dalian,China©2011ElsevierB.V.Allrightsreserved.5.35.1Introduction4445.35.2StemCellTransplantationArea4455.35.2.1TransplantSurgeryRoom4455.35.2.1.1Design4455.35.2.1.2Deviceconfig

2、uration4455.35.2.2CellProcessingArea4475.35.2.2.1Design4475.35.2.2.2Deviceconfiguration4475.35.2.3StemCellCollectionRoom(Class10000)4475.35.2.3.1Deviceconfiguration4475.35.2.4ClinicalPolymeraseChainReactionLaboratory4475.35.2.5SecondaryArea4485.35.2.5.1Steriledressingregion4485.35.2.5.2Stemcel

3、lstherapycenter4485.35.2.6DesignHighlights4495.35.3StemCellsandRegenerativeMedicineTechnologyResearchCenterDesign4495.35.3.1CellCultureLaboratoryDesign4495.35.3.1.1Laboratorydesignrequirements4495.35.3.1.2Facilitiesincellculturelab4515.35.3.1.3Supportingfacilities4515.35.3.2P2LaboratoryDesign4

4、515.35.3.2.1Layout(first-classbarricade)4525.35.3.2.2Automaticdoorlocker4525.35.3.2.3Maintechnicalparameterscontrolroom4525.35.3.3OpenLaboratoryDesign4525.35.3.4CellBankDesign4525.35.3.4.1Deviceconfiguration4535.35.3.5RegenerativeMedicineMaterialsResearchRoomDesign4535.35.3.6SupportFacilitiesD

5、esign4535.35.3.6.1ITroom4535.35.3.6.2Medicalhousing4535.35.3.6.3Watersystemcenter4535.35.4Conclusion454References454Glossaryhereditarydiseases,withorwithouttheadditionofgenebiosafetylevelBiosafetylevelsconsistoflaboratorytherapy.practicesandtechniques,safetyequipment,andacleanroomAcleanroomisa

6、nenvironment,typicallyusedlaboratoryfacilityappropriatefortheoperationsinmanufacturingorscientificresearchthathasalowlevelofperformedandthehazardposedbytheparticularenvironmentalpollutantssuchasdust,airbornemicrobes,biohazardmaterial.TheCentersforDiseaseControlaerosolparticles,andchemicalvapor

7、s.Cleanroomsare(CDC)andtheNationalInstitutesofHealth(NIH)defineclassifiedaccordingtothenumberandsizeofparticlesthefourbiosafetylevelsinthepublication,Biosafetyinpermittedpervolumeofair,suchas‘class100’or‘class1000’.MicrobiologicalandBio