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1、StemCellBiologyEDITEDBYDanielR.Marshak•RichardL.Gardner•DavidGottliebCOLDSPRINGHARBORLABORATORYPRESS本电子版仅供网友内部交流Glioma医网琴声http://www.dnathink.orgPrefaceThefieldofstemcellresearchhasattractedmanyinvestigatorsinthepastseveralyears.Progressinembryology,hematology,neurobiolog
2、y,andskeletalbiology,amongmanyotherdisciplines,hascenteredontheiso-lationandcharacterizationofstemcells.Theapproachingcompletionofthesequencingofthehumangenomehaslentfurtherimpetustoexplor-inghowgeneexpressioninstemcellsrelatestotheirdualfunctionsofself-renewalanddifferen
3、tiation.TwosmallmeetingsheldattheBanburyCenterofColdSpringHarborLaboratoryin1996and1999servedtobringtogethergroupsofscientistseagertodiscusstheroleofstemcellsindevelopment,tissuehomeostasis,andregeneration.Thesemeetingshighlightedboththequickeningpaceofdiscoveryrelatingto
4、thebasicbiologyofstemcellsandtheincreasingscopefortheirclinicalexploitation.Theyalsocon-vincedusthatitwastimelytoassembleamonographthatwouldhelptomakethefundamentalsofstemcellbiologymoreaccessibletothoseseekingbetteracquaintancewiththesubject.WethankInezSialiano,PatBarker
5、,DannydeBruin,andJohnInglisoftheColdSpringHarborLaboratoryPressforenablingthisprojecttoberealized.WealsoacknowledgetheeffortsoftheentirestaffofthePresswhocontributedtotheeditingandproductionprocess.Drs.JamesWatson,BruceStillman,andJanWitkowskiwerehighlysupportiveofthisent
6、erprise.AparticularnoteofthanksisdueMr.JamesS.Burnsforhisencouragementandenthusiasm,aswellashisvisionandaccomplish-ments,inboththedevelopmentofstemcellresearchanditspracticalexploitation.Finally,wethankourauthorsforagreeingsogenerouslytotakethetimetocontributetothisvolume
7、,andourfamiliesfortheirpatiencethroughoutitsgestation.D.R.MarshakR.L.GardnerD.GottliebixContentsPreface,viiSectionI:GeneralIssues1Introduction:StemCellBiology,1DanielR.Marshak,DavidGottlieb,andRichardL.Gardner2DifferentiatedParentalDNAChainCausesStemCellPatternofCell-type
8、SwitchinginSchizosaccharomycespombe,17AmarJ.S.Klar3OnEquivalenceGroupsandtheNotch/LIN-12Communic
