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1、BeksacMETHODSINMOLECULARMEDICINETMMETHODSINMOLECULARMEDICINETMSeriesEditor:JohnM.WalkerBoneMarrowandStemCellTransplantationBoneMarrowandStemCellTransplantationEditedbyBoneMarrowBoneMarrowMeralBeksacDepartmentofHematology,SchoolofMedicine,AnkaraUniversity,Ankara,TurkeyT
2、hisvolumeisacompendiumofcutting-edgemolecularmethodsforthesuccessfultransplantationofhematopoieticstemcells.Theavailabilityofgeneticprofilesforcommittedanduncommittedstemcellsandandcombinedwiththedeterminationofmolecularstepsinvolvedinhematopoieticstemcellactivationand
3、self-renewalholdtremendouspromiseforfuturesuccessintheclinic.Currently,stemcellscanbequantifiedandsortedsuccessfully,buttransduction,labeling,andinvivotrackingofstemcellsaredifficulttechniqueswithtraditionallylowefficiencylevels.Thecontributorstothisvolumedescribepromi
4、singtoolsforstemcelltransplantresearchmodels,suchasinvivobioluminescenceimaging.Topicsincludedinthisvolumearemolecularprofilingofhematopoieticstellcells,methodsforimagingcellStemCellStemCellfatesinhematopoiesis,PCR-SSPtypingofHLAClassIandClassIIalleles,sequence-basedHL
5、Atyping,andtypingminorHLAantigens.Alsodiscussedinthisvolumearetherolesofnaturalkillercellsandkillerinhibitorreceptorpolymorphisms,polymorphismswithinepithelialreceptors,molecularmethodsusedforthedetec-tionofautologousgraftcontaminationinlymphoiddisorders,andtheapplicat
6、ionofproteomicstoposttrans-plantationfollow-up.TransplantationTransplantationWiththerecenttrendmovingfromgeneexpressiontotheproteinexpressionprofiles,theapplicationofproteomicstotheposttransplantfollow-upofpatientsisbecomingroutine.Asaresult,thisvolumewillbecomeaninval
7、uablesourceforbiochemists,molecularbiologists,andclinicians.Features•DiscussionofHLAtyping,PCR-SSPtyping,•Chapterswrittenbyworld-renownleadersHLAantigensinthefieldEditedbyEditedbyContentsMolecularProfilingofHematopoieticStemCells.morphisms:AssociationofHLAandKIRs.Ident
8、ifica-MeralBeksacMeralBeksacMethodsforImagingCellFatesinHematopoiesis.tionofBoneMarrowDerivedNonhematopoieticAnOvervi
