5.32 Stem Cell Therapy to Treat Heart Failure

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1、5.32StemCellTherapytoTreatHeartFailureGFöldes,ImperialCollegeLondon,London,UKandSemmelweisUniversity,Budapest,HungarySEHarding,ImperialCollegeLondon,London,UK©2011ElsevierB.V.Allrightsreserved.5.32.1Introduction–Cell-BasedTherapyforCardiacDisease4075.32.2MajorUnmetandCom

2、pellingClinicalNeedDrivesStemCellResearchandTrialsinHeartFailure4085.32.3CurrentTherapiesinHeartFailure4085.32.4MechanismsofCardiacRegeneration4085.32.5WhichStemCellsTypeCanBeSuitableforCardiacCellTherapy?4095.32.5.1ActionsofBoneMarrow-DerivedHematopoieticStemCells:Parac

3、rineEffects4095.32.5.2MesenchymalStemCells4095.32.5.3EndothelialProgenitorCells4115.32.5.4SkeletalMyoblasts4125.32.5.5ESCsandDerivatives4125.32.5.6InducedPluripotentStemCellsandDerivatives4135.32.5.7Cardiac-ResidentStemCells4135.32.6CellDelivery4145.32.7ClinicalTrialswit

4、hBoneMarrow-DerivedStemCells4145.32.8ConclusionsandFutureChallenges415Acknowledgment417References417GlossarybelongedtoiskeptbyathirdpartyuntilthestudyisallogeneicstemcelltransplantationAprocedureincompleted.whichapersonreceivesstemcellsfromageneticallyleftventricularejec

5、tionfractionIncardiovascularsimilar,butnotidenticaldonor.physiology,ejectionfractionisthefractionofbloodautologoustherapyTissuetransplantedbyautologouspumpedoutofaventriclewitheachheartbeat.procedureisasituationinwhichthedonorandrecipientmyocardialinfarctionAnocclusionor

6、blockageofarethesameperson.arteriessupplyingthemusclesoftheheart,resultingincellproliferationThetermisusedinthecontextsofcellinjuryornecrosisoftheheartmuscle.developmentandcelldivision.ItreferstogrowthofcellparacrineDenotingatypeofhormonefunctioninwhichpopulations,whereo

7、necellgrowsanddividestoproducehormonesynthesizedinandreleasedfromendocrinecellstwo.bindstoitsreceptorinnearbycellsandaffectstheirfunction.crossoverstudyItisalongitudinalstudyinwhichprogenitorcellIndevelopment,aparentcellthatsubjectsreceiveasequenceofdifferenttreatmentsor

8、givesrisetoadistinctcelllineagebyaseriesofexposures.celldivisions.Incontrasttostemcells,progenitorcells