资源描述：
《[doi 10.1016-B978-0-12-387664-5.00003-0] Schenten, Dominik -- [Advances in Immunology] Volume 109 The Control of Adaptive Immune Responses by the Innate Immune System》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、CHAPTER3TheControlofAdaptiveImmuneResponsesbytheInnateImmuneSystemDominikSchenten*andRuslanMedzhitov*Contents1.Introduction882.DiverseSetsofPRRs892.1.TransmembranePRRs902.2.CytosolicPRR933.Cell-Type-SpecificPRRDistributionandtheInterplayBetweenPRRsinAd
2、aptiveImmunity97þ4.InnateControlofCD4TCellResponses99þ4.1.Cell-autonomouscontrolofCD4Tcellresponses100þ4.2.IndirectcontrolofCD4Tcellresponses1015.BCell-IntrinsicControlofHumoralImmuneResponsesbyPRRs1066.PathologicalConsequencesofDefectivePRRSignalingin
3、Humans1087.Conclusions110Acknowledgments111References112AbstractThemammalianimmunesystemcomprisesanadaptiveandaninnatecomponent.Theinnateimmunesystememploysalimitednumberofgerm-line-encodedpattern-recognitionreceptors(PRRs)thatrecognizeinvariantpathoge
4、n-associatedmolecularpatterns(PAMPs).Incontrast,theadaptiveimmunesystemdependsonthe*HowardHughesMedicalInstituteandDepartmentofImmunobiology,SchoolofMedicine,YaleUniversity,NewHaven,Connecticut,USAAdvancesinImmunology,Volume109#2011ElsevierInc.ISSN0065
5、-2776,DOI:10.1016/B978-0-12-387664-5.00003-0Allrightsreserved.8788DominikSchentenandRuslanMedzhitovgenerationofadiverserepertoireofantigenreceptorsonTandBlymphocytesandsubsequentactivationandclonalexpansionofcellscarryingtheappropriateantigen-specificr
6、eceptors.Inductionofadaptiveimmunitynotonlydependsondirectantigenrecognitionbytheantigenreceptorsbutalsoreliesonessentialsignalsthataredeliveredbytheinnateimmunesystem.Inrecentyears,wehavewitnessedthediscoveryofastillexpandingarrayofdifferentPRRsystems
7、thatgovernthegenerationofadaptiveimmunity.Here,wereviewourcurrentunderstandingofinnatecontrolofadaptiveimmunity.Inparticular,wediscusshowPRRsinitiateadaptiveimmuneresponsesingeneral,discussspecificmechanismsthatshapetheensuingTandBcellresponses,andhigh
8、lightopenquestionsthatarestillawaitinganswers.1.INTRODUCTIONDefenseagainstmicrobialassaultsisanessentialnecessityforalllivingorganisms.Consequently,alllifeformshaveevolvedstrategiesthataredesignedtolimittheinvasionofthehostbymicroorgani
![[doi 10.1016-B978-0-12-387664-5.00003-0] Schenten, Dominik -- [Advances in Immunology] Volume 109 The Control of Adaptive Immune Responses by the Innate Immune System_第1页](https://f25.wenku365.com/file-convert/2021/07/10/20/03/b90113424299edcbfe2f31dfa7a1c4ed/img/1.jpg)
![[doi 10.1016-B978-0-12-387664-5.00003-0] Schenten, Dominik -- [Advances in Immunology] Volume 109 The Control of Adaptive Immune Responses by the Innate Immune System_第2页](https://f25.wenku365.com/file-convert/2021/07/10/20/03/b90113424299edcbfe2f31dfa7a1c4ed/img/2.jpg)
![[doi 10.1016-B978-0-12-387664-5.00003-0] Schenten, Dominik -- [Advances in Immunology] Volume 109 The Control of Adaptive Immune Responses by the Innate Immune System_第3页](https://f25.wenku365.com/file-convert/2021/07/10/20/03/b90113424299edcbfe2f31dfa7a1c4ed/img/3.jpg)
![[doi 10.1016-B978-0-12-387664-5.00003-0] Schenten, Dominik -- [Advances in Immunology] Volume 109 The Control of Adaptive Immune Responses by the Innate Immune System_第4页](https://f25.wenku365.com/file-convert/2021/07/10/20/03/b90113424299edcbfe2f31dfa7a1c4ed/img/4.jpg)
![[doi 10.1016-B978-0-12-387664-5.00003-0] Schenten, Dominik -- [Advances in Immunology] Volume 109 The Control of Adaptive Immune Responses by the Innate Immune System_第5页](https://f25.wenku365.com/file-convert/2021/07/10/20/03/b90113424299edcbfe2f31dfa7a1c4ed/img/5.jpg)
