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1、第42卷第6期哈尔滨医科大学学报Vol.42,No.62008年12月JOURNALOFHARBINMEDICALUNIVERSITYDec.,2008625临床研究磁共振单体素波谱在颞叶癫痫诊断中的应用3夏清艳,刘鹏飞,王巍(哈尔滨医科大学第一临床医学院磁共振科,黑龙江哈尔滨150001)[摘要]目的评价单体素氢质子磁共振波谱(single2voxelhydrogenprotonmagneticresonancespectroscopy,SVS)诊断颞叶癫痫(temporallobeepilepsy,TLE)的价值。方法设对照组24例,颞叶癫痫组24例。应用1.5T场
2、强的磁共振(magneticresonance,MR)设备分别对双侧海马结构(hippocampusformation,HF)行氢质子波谱采集。比较TLE患侧组、对侧组及对照组各代谢物比值,并行致痫灶定侧诊断。结果TLE患侧组的N2乙酰天门冬氨酸/胆碱+肌酸[N2acetylasparte/(choline+creatine),NAA/(CHO+Cr)](0.46±0.08)、N2乙酰天门冬氨酸/肌酸(N2acetylas2parte/creatine,NAA/Cr)(0.92±0.23)下降,与对侧组、对照组(分别为0.57±0.10、1.26±0.22;0.67±0
3、.08、1.47±0.10)差值有显著性意义(t值分别为6.88、7.94,P<0.01)。结论SVS是一种无创性探测脑组织内生化物质改变的方法,对颞叶癫痫的定侧诊断具有很大价值。[关键词]单体素磁共振波谱;颞叶癫痫;诊断[中图分类号]R742.1[文献标识码]A[文章编号]1000-1905(2008)06-0625-04Diagnosisoftemporallobeepilepsywithsingle2voxelhydrogenprotonmagneticresonancespectroscopyXIAQing2yan,LIUPeng2fei,WANGWei(Dep
4、artmentofMagneticResonance,TheFirstClinicalCollege,HarbinMedicalUniversity,Harbin150001,China)Abstract:ObjectiveToinvestigatethevalueofsingle2voxelhydrogenprotonmagneticresonancespec2troscopy,SVS)indiagnosingpatientswithtemporallobeepilepsy(TLE).MethodsFourty2eightcases(24normal,24tempor
5、allobeepilepsy)experiencedsingle2voxelhydrogenprotonmagneticresonancespectroscopy(SVS).ThestudyofvolumeofSVSwaspalcedovertheanteriorhippocampusformation(HF)region,includingpartoftheheadandbodyofHFon1.5magneticresonancesystem.Themetabo2litedatafromSVSwasobtainedandtheratiosofN2acetylaspar
6、te/(choline+creatine)(NAA/CHO+Cr),andN2acetylasparte/creatine(NAA/Cr)wererecordedandcalculated.ResultsTheipsilateralepiletogeniczoneofpatientsshowedlowerratiosofNAA/(Cho+Cr)andNAA/Cr,andthedifferencescomparedwiththoseofthenormalgroupandcontralateralsubgroupwerestatisticallysignificant(t=
7、6188,P<0101andt=7194,P<0.01,respectively).ConclusionSVScanprovidebiochemicalandmetabolicinformationforthepreoperativeinvesitigationonpatientswithTLE.Keywords:magneticresonancespectroscopy;epilepsytemporallobe;diagnosis癫痫是临床常见的一种病因复杂的反复发作的80%的顽固性癫痫患者的癫痫发作得到控制或完全[1]神经系统疾病。发
