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1、HBV基因型在HBV感染性肝癌及慢性HBV感染自然史的不同阶段的分布黄亚琴,杨丽莎,吴淋玲(541001广西桂林,桂林医学院附属医院消化内科)[摘要]目的探讨乙型肝炎病毒(hepatitisBvirus,HBV)基因型在HBV相关性肝细胞癌(hepatocellularcarcinoma,HCC)及慢性HBV感染自然史不同阶段的分布。方法选择广西桂北地区46例HBV感染相关性HCC患者,慢性HBV感染自然史不同阶段者共90例,通过实时荧光定量PCR鉴定HBV基因型。临床实验室检查结果和病理资料摘抄自患者病案
2、。结果本地区慢性HBV感染者中基因型B占77.8%,基因型C占18.9%,非B非C(3.3%),HCC中基因型B占78.3%,基因型C占21.7%,慢性HBV感染者和HCC之间的基因型分布差异无统计学意义(P>0.05);慢性HBV感染不同阶段者之间的基因型分布差异无统计学意义(P>0.05);慢性HBV感染者中基因型B、C比较,临床资料差异无统计学意义(P>0.05),HCC中基因型B、C间HBV-DNA比较差异有统计学意义(P<0.01);慢性HBV感染不同阶段组和HCC组比较,ALT、AST、TBIL
3、、ALB、年龄,性别差异均有统计学意义(P<0.05)。结论广西桂北地区的慢性HBV感染者和HBV相关性肝癌以基因型B为主,基因型在HBV感染自然史不同阶段和HCC对比分布无差别。基因型C的HBVDNA水平更高。[关键词]肝炎病毒,乙型;基因型;癌,肝细胞;广西[中图法分类号]R735.7 [文献标志码]ADistributionofHBVgenotypesinHBVinfection-associatedhepatocellularcarcinomaandindifferentphasesofnatur
4、alchronicHBVinfectionhistoryHuangYaqin,YangLisha,WuLinling(DepartmentofGastroenterology,AffiliatedHospitalofGuilinMedicalCollege,Guilin541001,GuangxiZhuangAutonomousRegion,China)[Abstract]ObjectiveTostudythedistributionofHBVgenotypesinHBVinfection-associat
5、edhepatocellularcarcinoma(HCC)andindifferentphasesofnaturalchronicHBVinfectionhistory.MethodsHBVgenotypesin46patientswithHBVinfection-associatedHCCand90patientswithanaturalchronicHBVinfectionhistoryatdifferentphasesintheNorthernGuangxiZhuangAutonomousRegio
6、nwereidentifiedbyreal-timefluorescencequantitativePCR.Laboratoryfindingsandpathologicaldatawereobtainedfrommedicalrecordsofthepatients.ResultsGenotypesB,C,andnon-AandBaccountedfor77.8%,18.9%,and3.3%,respectively,inpatientswithchronicHBVinfection.GenotypesB
7、andCaccountedfor78.3%and21.7%inHCCpatients.NosignificantdifferencewasobservedindistributionofHBVgenotypesamongthepatientswithHBVinfection,HCC,andchronicHBVinfectionatdifferentphases(P>0.05).AsignificantdifferencewasfoundinHBV-DNAbetweengenotypesBandC(P<0.0
8、1).TheALT,AST,TBIL,ALB,andagelevelsweresignificantlyhigherinHCCpatientsthaninthosewithchronicHBVinfectionatdifferentphases(P<0.05).ConclusionGenotypeBisdominantinpatientswithchronicHBVinfectionandHBVinfection