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时间:2019-05-29
《常规二维放疗和三维适形调强放疗对食管癌的疗效分析》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、万方数据·22·.享2..峥囊.詈.挚参未..2013年第17卷第3期Jo唧al0fClinicalMedicineinPractice⋯。。/1。⋯州⋯。常规二维放疗和三维适形调强放疗对食管癌的疗效分析叶奕菁,张晶晶,陆小军,徐桂琼,欧阳玉秀,刘玉猛(广东省中山市人民医院肿瘤放疗科,广东中山,528403)摘要:目的探讨三维适形调强放疗(3D-IMRT)与二维常规放疗治疗食管癌的临床效果及安全性。方法86例食管癌患者随机分为3D-IMRT组和二维常规放疗组(普放组),比较2组近期疗效、远期疗效和毒
2、副反应的差异。结果3D—IMRT组总有效率显著高于普放组;普放组放射性肺炎发生率显著高于3D—IMRT组;3D—IMRT组1、2、3、5年局部控制率及1、2、3年生存率显著高于普放组。结论与二维常规放疗比较,3D.IMRT能明显改善食管癌的近期疗效,提高局部控制率和生存率,并能有效减轻周围组织放疗损伤。关键词:适形调强放疗;常规放疗;食管癌中图分类号:R735.1文献标志码:A文章编号:1672.2353(2013)03_022_03DOI:lO.7619/jc”p.201303007An肌alys
3、is0fthetherap伽tice仃ects0fthree—dime砸ionalintensitymodlllatedradiationtherapyandtwo—dimensionalconVentionalradiotherapyonesophagealcarcinomaⅦYijing,ZInNGJiIl西ing,LU】
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5、T:ob口ectiVeToexplorethetherapeutice]自[Iectsandsafetyofthree—dimensionalin-tensitymodulatedradiationtherapy(3D-IMRT)a11dtwo—dimensionalgeneralradiother印yones叩ha—gealcarcinoma.】!uethOdsEighty—sixesophageaLlcancerpatientsweredividedintotwogroups:3D—IMRTgm
6、upandtwo—dimensionalconVentionalradiotherapygmup(generalradiotherapygmup).Thedi珏.erencesbetweenshort—temandlong—temther印eutice珏宅ctsasweUastoxieandsideefkctsintwogroupswerecompared.ResllltsThetotaleff-ectivenessrateof3D—IMRTgroupsignificantlywashigherth
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8、diothempygroup.Conclu喀ionComparedwithtwo—dimensionalconventionalradiotherapy,3D—IMRTcanmarkedlyenhancetheshort—te珊therapeuticeff色ctsofesophagealcarcinoma,improveitslocalconn.0lmteandsuⅣiValmte,andefkctiVelyalleviatetlledamageofsurroundingtissuesinduced
9、byradiotherapy.KEYWOImS:intensitymodulatedradiationtherapy;conventionalradiotherapy;esophagealcaI_cinoma中国食管癌的治疗以手术切除和放疗为主,但食管癌常规分割放疗患者5年生存率仅为10%左右,后程加速超分割治疗患者5年生存率也仅为30%左右。手术和放疗失败的主要原因收稿日期:2012一12一13基金项目:中国高校医学期刊临床专项资金(11320005)为局部未控制和
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