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ID:36800057
大小:248.76 KB
页数:3页
时间:2019-05-15
《自体血清皮肤试验阳性慢性荨麻疹与HLA—DRB1基因的相关性研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、78堡廛志2!生2箍鲞笫2盟Feb~2Q2LlV_45上..2·论著·自体血清皮肤试验阳性慢性荨麻疹与HLA—DRB1基因的相关性研究吴易蒙金秋严煜林曹存巍刘栋华梁伶【摘要】目的探讨广西地区自体血清皮肤试验阳性慢性荨麻疹与HLA—DRB1等位基因遗传易感性的关系。方法对144例广西地区慢性荨麻疹患者进行自体血清皮肤试验,按试验结果分为阳性组62例,阴性组82例。采用聚合酶链反应一序列特异性引物方法,对患者组和199例正常人对照组进行HLA—DRB1等位基因的分型,并分析DRB1基因在3个组中的分布。使用SPSS13.0统计软件分析。结果DRBI*01
2、、1401、16等位基因频率在阳性组、阴性组和正常人对照组间比较,差异均有统计学意义(x=10.92,=0.03;x=35.34,Pc<0.叭;x:12.69,Pc=0.03)。进一步在各组问进行两两比较,仅DRB11401等位基因频率在自体血清皮肤试验阳性组与对照组间(RR=17.09,.<0.叭)及自体血清皮肤试验阳性组与阴性组问(nn=7.20,Pc<0.01),差异均有统计学意义。结论DRB11401等位基因可能是广西地区自体血清皮肤试验阳性慢性荨麻疹的易感基因或与其连锁。【关键词】荨麻疹;等位基因;基因,MHCⅡ类;皮肤试验Relation
3、shipbetweenHLA.DRB1allelesandchronicurticariawithpositiveautologousserumskintestWUYi,MENGJin-qiu,YANYu-hn,CAOCun—wei,uUDong—hua,UANGLing.DepartmentofDermatologyandVenereology,FirstAmliatedHospitalofGuangxiMedicalUniversity.Nanning53oo21.ChinaCorrespondingauthor:WUYi.Email:wuyin
4、nn@J63.eom【Abstract】0bjecfiveToinvestigatetherelationshipbetweenHLA—DRB1allelesandchronicurticariawithpositiveautologousserumskintest(ASST)inGuangxiZhuangAutonomousRegion.MethodsASSTwasconductedin144patientswithchronicurticaria.whoweresubsequentlydividedintotwogroupsaccordingto
5、thetestresult:positivegroup(n=62)andnegativegroup(n=82).PCRamplificationwithsequence—specificprimerswasusedtodeterminethegenotypesofHLA.DRB1allelesinthepatientsand199normalhumancon—trols.Chi—squaretestwasperformedtoanalysethediferenceinthefrequencyofHLA—DRB1allelesbetweentile3g
6、roupsbyusingtheSPSS13.0statisticalsoftwarepackage.ResultsThereweresignificantdifferencesinthe~equencyofHLA.DRB1*01.1401and16allelesamongthepatientswithpositiveandnegativeASSTandthecontrols(=10.92,Pc=0.032;=35.34,Pc<0.01;=l2.69,=0.032).Pairedcomparisonre—vealedsignificantdiffere
7、ncesinthefrequencyofHLA.DRB11401allelebetweenthepatientswithpnsitiw~ASSTandcontrols(RR=17.09.只<0.01)aswellasbetweenthepatientswithpositiveandnegativeASST(RR=7.20,Pc<0.o1).ConclusionHLA.DRB11401allelemaybe,orbelinkedto,thepredisposinggeneofchronicurticariawithpositiveASSTinGuang
8、xiZhuangAutonomousRegion.【Keywords】Urticaria;Alleles;G
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