妊娠期糖尿病胰岛自身抗体阳性与hla―drb1基因型相关探析

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1、妊娠期糖尿病胰岛自身抗体阳性与HLA-DRB1基因型相关探析［摘要］H的探讨妊娠期糖尿病胰岛自身抗体阳性与HLA-DRB1的关系。方法选取2013年6月一2016年6月期间在该院进行产检的孕妇作为研究对象，共有102例。将其分为对照组与观察组。对照组为非自身免疫性GDM孕妇，有61例。观察组为自身免疫性，抗体阳性，共有41例。比较两组GDM孕妇的妊娠结局和产后6周血糖情况。结果与对照组孕前相比，观察组孕妇的BMI较低，妊娠失风险系数高。两组GDM的HLA-DRB1基因频率相比，差异无统计学意义。与正常人群相比，两组的HLA-DRB1X04频率更高。差异有统计学意义（P〈0.05

2、）。最后，自身抗体显示阳性的，妊娠难度高。两组在胰岛素使用频率上,差异无统计学意义（P〉0.05）。对比产后血糖的恢复情况，差异无统计学意义。结论GDM属于多基因疾病，在遗传上有异质性，受到生活习惯、环境等因素的影响。同时，也还受到转归差异的影响。所以，必须加强随访、后期跟踪，认真研究此类妇女的远期预后，以便进行早期干预，延缓发病时间。本文采集自网络，本站发布的论文均是优质论文，供学习和研究使用，文中立场与本网站无关，版权和著作权归原作者所右，如存不愿意被转载的情况，请通知我们删除己转载的信息，如果需要分享，请保留本段说明。［关键词］HLA-DRB1;妊娠；糖尿病胰岛；自身抗体

3、；阳性；基因；分析［中图分类号］R714.25［文献标识码］A［文章编号］1672-4062(2016)11(b)-0001-02［Abstract］ObjectiveTostudythecorrelationbetweenthediabetesIsletantoantibodypositiveinthegestationperiodandHLA-DRB1genotype.Methods102casesofpregnantwomenwithantenatalcareinourhospitalfromJune2013toJune2016wereselectedastheresea

4、rchobjectsanddividedintotwogroups，thecontrolgroup(61cases)werethenon-autoimmuneGDMdeliverywomenwith61cases,whiletheobservationgroupweretheantoantibodypositivedeliverywomenwith41cases,andthepregnantoutcomeofGDMdeliverywomenandbloodsugarafterpostpartum6weekswerecomparedbetweenthetwogroups.Resu

5、ltsTheBMIintheobservationgroupwaslowerthanthatinthecontrolgroup,andthepregnantriskfactorwashigherintheobservationgroup,andthedifferenceintheHLA-DRB1genefrequencybetweenthetwogroupswasnotobvious,andtheHLA-DRB1X04frequencyofthetwogroupswashigherthanthatofthenormalpopulation,andthedifferencewas

6、obviouswithstatisticalsignificance(P<0.05),finally,theantoantibodywaspositiveandthepregnantdifficultyishigh,andtherewasnoobviousdifferenceintheusefrequencyofinsulinwithoutstatisticalsignificance(P>0.05),andthedifferenceintherecoveryofPostpartumbloodglucosehadnostatisticalsignificancebycompar

7、ison.ConclusionGDMbelongstothemultigenicdiseasewithheterogenicitygenetically,affectedbythelivinghabits,environmentandoutcomedifference,therefore,wcmustenhancethefollowingandlatetrackingcarefullyresearchthelong-termprognosisofthesewomeninordertocarr