麻醉大鼠肠系膜微环境碱化对微血管反应性的影响

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1、学校代码：10114分类号：R96硕士学位论文麻醉大鼠肠系膜微环境碱化对微血管反应性的影响EffectofAlkalizationinAnestheticRatMesentericMicroenvironmentonMicrovascularReactivity研究生：李怡欣指导教师：张轩萍教授专业名称：药理学研究方向：心血管药理学学位类型：科学学位所在学院：基础医学院中国·山西二〇一三年三月十五日山西医科大学硕士学位论文分类号：单位代码：10114密级：学号：201010053麻醉大鼠肠系膜微环境碱化对微血管反应性的影响E

2、ffectofAlkalizationinAnestheticRatMesentericMicroenvironmentonMicrovascularReactivity研究生：李怡欣指导教师：张轩萍教授申请学位门类级别：医学硕士（科学学位）专业名称：药理学研究方向：心血管药理学所在学院：基础医学院二〇一三年三月十五日山西医科大学硕士学位论文山西医科大学硕士学位论文目录中文摘要···········································································

3、·············Ⅰ英文摘要······················································································Ⅳ正文······················································································1前言·····································································

4、··················1材料与方法·················································································3结果··························································································12讨论·······························································

5、···························18结论························································································31参考文献·····················································································37综述···················································

6、································40正文·······················································································40参考文献·····················································································52个人简介·············································

7、·········································55致谢······················································································56山西医科大学硕士学位论文麻醉大鼠肠系膜微环境碱化对微血管反应性的影响摘要目的：观察麻醉大鼠肠系膜微环境在碱化时，pH值增加对微动、静脉血管反应性的影响；同时观察不同pH值对血管活性药物去甲肾上腺素（Norepinephrine，NE）、硝普钠（Sodiumnitr

8、oprusside，SNP）诱导微动、静脉血管反应性改变的影响。方法:应用BI-2000医学图像分析系统，采集活体麻醉大鼠肠系膜微循环显微图像，观察不同处理因素下大鼠肠系膜微血管直径的变化。实验分为三部分。1、第一部分，大鼠肠系膜微环境碱化时，pH值增加（pH7.6、7.8、8.0、8.2