超临界流体技术制备纳米布洛芬与其与多孔材料的复合制剂

《超临界流体技术制备纳米布洛芬与其与多孔材料的复合制剂》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、AbstractPEG2000toPEG6000)，andsignificantlyincreaseswiththeflowrateofthegas—saturatedsolutionortheibuprofencontentintheibuprofen／PEG6000mixture，whilethetemperatureshowslittleeffectonthesizeintheinvestigatedrange．TheeutecticcompositionofPEG6000一ibuprofendoesnotshowspecialeffectonthe

2、particlesizeormorphologyoftheproducedibuprofennanoparticles．TheibuprofennanoparticlesobtainedfromthemodifiedPGSSTM-basedprocessshowmuchfasterdissolutionratethantheibuprofenrawmaterialandtheibuprofenparticlesfromadirectmixingprocessinthesimulatedgastricjuice(hydrochloricacidandpota

3、ssiumchloridebuffersolutionwithpH=1．4土0．02)，simulatedintestinalfluid(phosphatebuffersolutionwithpH=7．2士0．02、andsimulatedcontinuousdissolution．Theloadingratioofibuprofenintwoloadingmaterials，viz．Si02and13-cyclodextrin(13-CD)Wasinvestigatedundervariousconditions(10adingtime，loadingp

4、ressureandloadingtemperature)byusingasolute—saturatedsupercriticalfluidloading(SSFL)technique．Resultsshowedthatthesaturatedloadingtimeathighpressure(15．0MPa)andlowpressure(8．0MPa)arelessthan15hand20hrespectively；amongtheinvestigatedconditions，theloadingratioofibuprofeninSi02and13-

5、CDincreasesfollowingtheincreaseoftheloadingtemperatureorpressureatlowpressure(1essthan17．0MPa)，anddecreasesalittleastheincreaseoftheloadingpressureafter17．0MPa；andthemaximumloadingratiosCanbeashighas3。01gibuprofen／gSi02and0．157gibuprofen／gJ3-CD．respectively．SEMresultsshowthatthere

6、isnoobviousporestructurechangeofthetwoloadingmaterialsaftertheSSFL．ThedissolutiontestinhydrochloricacidandpotassiumchloridebuffersolutionwithpH=1．4士0．02demonstratesthatibuprofenin13-CDreleasesfasterthanthatinSi02，andibuprofeneitherin13-CDorinSi02showsfastreleaseincomparisonwiththe

7、ibuprofenrawmaterial．However,thedissolutionrateslowsdownfortheibuprofenpowdersobtainedathigherloadingpressureortemperature．Keywords：supercriticalfluid；ibuprofen；nanoparticles；loading；compositeparticles目录第一章文献综述⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯11．1难溶性药物⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．．11

8、．1．1传统药物纳米颗粒制备⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯