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ID:33089638
大小:5.83 MB
页数:50页
时间:2019-02-20
《激活shh通路对急性脑缺血大鼠突触再生的影响》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、AbstractEffectofactivatingtheSHHpathwayonexpressionsynapticregenerationinratswithacutecerebralischemiaPostgraduate:LiuHuayanSupervisor:LouJiyu,WangYuzhouDepartmentofNeurology,TheSecondAffiliatedofZhengzhouUniversityZhengzhou450014,HenanDepartmentofNeurology,TheCentralHospitalofJia
2、ozuo454002,HenanBackgroundand0bjectiveAsthesociMandlifestylechanges,themorbidityofcerebrovasculardiseaseareontheriseeveryyear,andtendtobeyoungeLnotonlyleadtoaheavyburdentothecommunityandfamilies,butalsothepsychologicalburdentopatients.Ischemicisthemostcomnlontypeofthecerebrovascul
3、ardisease,whichfeaturesinitshighmorbidity,mortalityandteratogenicrate.Withregardtothecountermeasure,earlydiagnosisandaggressivetreatment,rehabilitationexercisestostrengthenandpreventrecurrenceareessential.Withthecontinuousresearchofneuralprosthetics,nerveregeneration,especiallysyn
4、apticregeneration,isofgreatsignificancetotheischemiccerebrovasculardisease.Recentstudiesindicate,Shhsignaltransductionpathwayandischemiccerebrovasculardiseasemostlikelyhassignificantcorrelationsonthesynapticregenerationperformance.Shhsignalpathincludesthreeprincipalparts-asignalpe
5、ptideShh,thefilmfactorPtch、SmoanddownstreamtranscriptionfactorGli,thecascadeactsorthemutationsoffactorscanactivatethispathway,andeffectsonIVAbstractdownstreamtargetgenesthroughtheGlifinally.ActivationofShhsignalingpathwayhasaprotectiveeffectoncerebralischemia,Callpromotetheregener
6、ationandreconstructionofsynapsesandencouragetherestorationofneurologicalfunction.Thence,thepresentstudytakemethodofLongatomakepermanentischemiamodelinrats,toobservetheexpressionofGlil—downstreammolecularofSonicHedgehogsignalingpathwayandSYN,GAP一43-一synapticassociatedsynthesisprote
7、insinischemicpenumbraatdifferenttimepointsafterapplywiththespecificactivatorPurmorphamine,thus,tofurtherexploretheeffectsandmechanismofShhsignalingpathwayinfluencedonthesynapticregenerationoftheischemiccodex.MaterialsandMethodsPermanentmiddlecerebralareteryocclusionmodelswereprodu
8、cedbysutureembolitechniqueinrats.
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