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ID:33086503
大小:5.58 MB
页数:41页
时间:2019-02-20
《鼻咽癌患者血浆eb病毒dna定量检测与其临床意义》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、鼻咽癌患者血浆EB病毒DNA定量检测及其临床意义中山大学硕士学位论文QuantificationDetectionandClinicalSignificance-蹩薹!耋萋簦辇摹妻鏊蓁耋饕l蚕一霎萋孚塞搿;茎妻墨羹囊糯;粪矬耋i囊薹薹薹薹蠢冀冀錾薹l蓁嚣妻萋l蔷
2、上尽囊型薹喜鎏l零喜萎耋i妻蓁藿藿藏薹!冀薹薹羹lzl塞薹"xVC~IgAalldE~IgA舶m84healthycontmls.2.P1aSmawerecollected舶m149post-treatmentNPCpatientswhoweretreatedinourhospitalbet、vee
3、nDecember2006toDecember2007including60metastasispatients,29locoregionalrecurrencepatlents,60remlsslonpatientswho、verefollo、vedupformorethall2years.Thesepatientswerediagnosedwiththeclinicalradiographicand/orpathologicallyeVidences.TheplasmawerecoIlectedtodetectionEBV—DNA、VCA/IgAandE
4、A/IgA.Amongthe60metastasispatients,PeripheralbloodwaScollectedf硒m16atevenr2cycleschemotherapyfinishedandassessresponsewithradiographic.3.ForEpstein—BallrVirusDNAinplasmawaSdetectedinreal.timequantitativePCRsystem;VCA/IgA、EA/IgAweretestedbyimmunonuorescenceexperiments.4.Inthe1l3new-
5、diagnosiedNPC,61caSeshadtwocyclesneoadjuvantchemotherapyandradiotherapy.52casesonlyhadradiotherapy.Theregimenofneoadjuv觚tchemotherapy、^,asconsistedofCispIatin20mg·(m2·d)。1ond1.d5and5.FU750mg‘(m2‘d).1,giVenasa5一daycontinuousin向sion.Theradiation、VasadministeredbyC060ybeamsor6-8MVphot
6、onbe锄s.TheradiationportalsencompassedthenasopharynxandadjacentregionsatriskoflocaltumorspreadaJldbothsidesneck.Theprescriptiondosetothenasopha巧nxgrosstumorwas68.74Gy;60Gyto64GythepositiVenecklymphnodes,and50Gyfbrprophylacticradiation,allusingconventionaldosef}actionation.TheSixteen
7、metastasispatientshadsixcycleschemother叩y.TheregimensofchemotherapywerePF、TPF、TP.5.Allstatistic羽analyseswerepe“bnnedwithSPSS13.OsoRware.ThemedianEBV.DNAwerecomparedusingnonparametrictest.Therate(proponion)werecomparedusingchi-squaretest.Atwo-tailedpvalueof8、callvsignificant.Results:PlasmaEBV二DNAwasdetectablein80%(90/l13)ofprima巧NPC,2.4%(2/84)ofheaIthycontr01.ThemediaJlplaSmaEBV-DNAconcentrationwaS34200copies/ml锄d0copies/ml,respectively.T11edi仃erencebet、)~reentheSet、vogroupsisstatisticaUysignificant⑦20.OOO).’I’ocomparetheReceiveroprati9、ngcharacteristic(ROC)cun,e
8、callvsignificant.Results:PlasmaEBV二DNAwasdetectablein80%(90/l13)ofprima巧NPC,2.4%(2/84)ofheaIthycontr01.ThemediaJlplaSmaEBV-DNAconcentrationwaS34200copies/ml锄d0copies/ml,respectively.T11edi仃erencebet、)~reentheSet、vogroupsisstatisticaUysignificant⑦20.OOO).’I’ocomparetheReceiveroprati
9、ngcharacteristic(ROC)cun,e
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