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ID:32378546
大小:932.68 KB
页数:18页
时间:2019-02-04
《中国hiv1感染者nkt细胞与疾病进展的相关性研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、与CD4+T细胞无显著相关,CD4+NKT细胞与CD4-NKT细胞呈显著正相关。HIV/AIDS患者NKT细胞与CD4/CD8的比值显著正相关(r--0.32,P<0.05)。结论1、中国HIV/AIDS患者NKT细胞数量在疾病末期显著下降,与疾病进展相关。2、中国缓慢进展者维持高水平NKT细胞数量可能为其疾病缓慢进展的原因之一。关键词HIV,AIDS,NKT细胞,CCR54·英文论著摘要·StudyontheRelationshipbetweenTCRVa24+Vpll+NKTCellsandtheProgressionofHIV-1Inf
2、ectioninChinesePopulationPrefaceAIDS(acquiredimmunodeficiencysyndrome,AIDS)isaimmunedefectdiseasecausedbyHIV(humanimmunodeficiencyvirus,HIV)whichstillcallnotbecompletelycuredandmakebreakthroughinthevaccineresearchrightnow.Thebasicreasonliesinthelackofessentialunderstandingo
3、ftheHWbiologyandthemechanismofhumanorganismimmunereactionsandtheinteractionsbetweenthem,especiallythekeyregulatorintheimmunesystemisstillbarelyknown.Inimmunesystem,theNKTcell(naturekillerTcell)expressextremelyrestrictedTCRrepertoire,inhumanconsistingofaVa24chainpreferential
4、lypairedwithaV131chail=l’whichcouldactivateTcells,BcellsandNKcell,whichisthebridgebetweeninnateandadaptiveinlmunesystem,whichisoneofthekeyregularcells.Thus,thoughNKTcellsarepresentatverysmallnumbersinperipheralblood(between0.01and1%ofperipheralbloodmononuclearcells),whichpl
5、ayimportantrolesinanti-virus,bacteria,fungus,parasite,tumor,andautoimmunediseases.SomereportssuggestthatduetotherelativelliglllevelofCCR5totheregularTcells,theperpetualactivatedstateofNKTcellsaremoreeffectivetargetsforR5-tropicHIV-1infectioninvivo.Co-administrationof0【·GalC
6、erwithsuboptimaldosesofDNAvaccinesgreatlyenhancedantigen—specificTcellandBcellresponses.Inall,NKTcellsmayplayaroleinthedevelopmentofHWinfectiondiseaseprogression.DuetothedifferenthereditybackgroundbetweenChineseandtheWesterner,thenumberofallkindsofcellandmoleculesnaybehighl
7、yvariable.InHIVinfectedChinese,therehasnostudyonthefrequencyofNKTcellsaccordingtodiseaseprogression.Inthepresentpaper,westudiedthefrequencyandCCR5levelofTCRV以4+Vp11扑ⅨTcellsandtheirrelationshiptothediseaseprogressionofHIV-1infectedpatientsinChina.5MaterialandMethods1.Studyob
8、jectsAtotalof53treatmentnaiveHIV-infectedpatientsfromHenanprovincesofChinawereenro
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