不同证型乳腺癌新辅助化疗疗效和ki67变化的临床的研究

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1、Cliniealstudybetweentheeffeetivenessand幻一67ehangingofneoadjuvantchemotheraPyofTCMsydromedlf]陌rentiationofbreastCanCerSPeeiality:SurgeryofTraditionalChinseMedieineAuthor:WangXiTutor:Prof.YangyiAbstractobjeetive:ThisstudywasdesignedtoanalyZetheeffeetivenessand

2、儿一67changingofneoadjuvantchemotheraPy(NCT)inbresstcancerPatienis，reviewedandfollowed一uPthePatients’ovralsurival(05)anddisease一freesurival(DFS)，initsTraditionalChineseMedieine(TCM)syndromedl月七rentiation.InordertoProvideindividualtreatmentforTCMsydromedifferen

3、tiationofbreastcancerandtoconductthecliniealtreatinent.Methods:TOobservethrity一onecasesoffemalebreastcaneerwerediagnosedbycorebioPsiesandaecePtedNCT(whateverchemotherapyregimensandcycles)andthenoPeratedfromAPril2007toJune2010.Andsignsforelassificationofs姆dro

4、meonTCMofbreasteancer:stronglyfragrantstagnatPhlegnlcongealing，ehongrenimbalanee，defieieneyofhealthyenergyandstheniaofevil.Collecting，assessingNCTeffectiveness，observingtheexPressionsof，thencomParativeanalysisthegeneralimformation·Pathologicalindex一儿一67、DFS

5、05andmakestatisticanalysisusingSPSS16.o.Resu一t:①Allthe31patientswerefemale，theagesdistributedfrom28一64years，themiddleagewas52years.TherewereStronglyfragrantstagnatPhlegmcongealing14eases，ehongrenimbalanee10cases，defieieneyofhealthyenergyandstheniaofevil7case

6、s.Therewereobviousdifl七renceintheageandthePrimarytumorsiZe.StronglyfragrantstagnatPhlegllleongealinghadtheyoungestmeanage，39.3土8.3years，defieieneyofhealthyenergyandstheniaofevilhadmostT3，·T4.(P<0.05).ThePatientsofthleeTCMs卯dromeshadnodifferenceonthemenoPausa

7、lstatUs、Pathologiealstage(TNMstage)、lylllPhnodehistoPat】lologietyPe，chemotherapycyelesoPerationmode(p>0.05).②AfterNeT，31patientshadtheoverallresponserate(OR)54.8%，thedefieieneyofhealthyenergyandstheniaofevilhadthelowestOR(P<0.05).Andobviouslydeereased(58.1%

8、VS.38.7%，P<0.05)，Defieieneyofhealthyenergyandstheniaofevilwiththe儿一67positivee却ressionhadthehighestOR(p<0.05).③TNMstagecouldbelowedbyNCT，andbethedrugsensitivitytesttochangethechemotherapyregimen