高血压病患者循环内皮微颗粒与大小动脉弹性功能关系的临床-研究

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1、中山大学硕士学位论文高血压病患者循环内皮微颗粒与大小动脉弹性功能关系的临床研究TheClinicalStudyofTheRelationshipbetweenCirculatingEndothelialMicroparticlesandArterialElasticityinPatientswithessentialhypertensionMajor：InternalMedicine(Cardiology)Name：SuChenSupervisor：ProfessorTaojunAbstractBack

2、groundsEssentialhypertensionisoneofthemostprevalentchronicandnoninfectiousdiseaseinChina．Theinjuryofacuteandchronictargetorganscausedbyhypertensionsuchashypertensionemergency,cardiovascularandcerebrovasculardiseases，isthemostcommoncauseofdeathinpeople．It

3、hasbeendemonstratedthatimpairmentofarterialfunctionandstructureisthecommonpathologicalbasicofbothhypertensionandhypertension-relatedtargetorgansinju哆Endothelialdysfunctionisinvolvedintheinitiationanddevelopmentofatherosclerosisandimpairmentofarterialelas

4、ticityisthestrongandindependentpredictorofcardiovascularandcerebrovascularevents．Arterialelasticity,alsocalledarterialcompliance，reflectsthediastolicfunctionofartery,dependingonthediameter，stiffnessandtheexpansibilityofartery．Itisnotonlyassociatedwiththe

5、leftventricleaflerload，systolicbloodpressure，diastolicbloodpressureandpulsepressure，butalsoreflecttheendothelialfunctionequally．Variouscardiovascularriskfactorssuchashypertension,hyperlipaemia,hyperglucose，smokingandaging，allcandecreasearterialelasticity

6、．Impairmentofarterialelasticityisasensitiveandspecificmarkerofearlyvascularinjury,andisalsoahighriskfactorofcardiovasculardisease．Therearemanynovelinvasivetechnologytomeasurethearterialelasticity,suchasPulseWaveVelocity(PWV)，Augmentation—IV—中山大学硕士学位论文高血压

7、病患者循环内皮微颗粒与大小动脉弹性功能关系的临床研究lndex(A1)，LargeArterialElasticityIndex(C1)andSmallArterialElasticityIndex(C2)．Alotofstudiesdemonstratethatbrachial—anklearteryPulseWaveVelocity(baPWV)isastrongpredictorofcardiovascularandcerebrovasculardiseases，whichindependento

8、ftraditionaicardiovascularriskfactors．Clreflectsthelargearterialfunction，C2reflectsthesmallaterialfunction．ThelessC1andC2，theworsearterialfunction．Impairmentofarterialelasticityinpatientswithhypertensionismainlycausedbythr