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ID:30910362
大小:161.00 KB
页数:9页
时间:2019-01-04
《rhamm在胆管癌侵袭和转移中的作用》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、RHAMM在胆管癌侵袭和转移中的作用陈波重庆市第九人民医院普外科(重庆400700)[摘要]目的:探讨透明质酸介导的细胞游走受体(RHAMM)在胆管癌浸润和转移中的作用。方法:收集临床上行胆管癌手术的患者的组织标本及正常胆管组织标本,根据病理分型以及TNM分期标准将其分为三个组,免疫组织化学及Westernblot法检测各组中RHAMM蛋白的表达水平。结果:免疫组织化学检测在不同病理类型的胆管癌中RHAMM均有不同程度的表达(P>0.05);RHAMM在胆管癌组和胆管癌伴转移组中阳性表达,位于胞膜或胞浆,在对照组表达弱阳性或阴性。Wes
2、ternblot检测RHAMM蛋白表达量在对照组为(0.033±0.003),胆管癌组为(0.162±0.013),两组差异无显著性(P>0.05)。在胆管癌伴转移组为(0.388±0.018),与其它两组比较差异有显著性(P<0.05)。结论:RHAMM的表达程度与胆管癌的病理类型无关,但在胆管癌伴转移组中的高表达可能与胆管癌的侵袭相关,并最终促进了胆管癌的转移。[关键词]透明质酸介导的细胞游走受体;胆管癌;侵袭;转移THEROLEOFRHAMMINTHEINVASIONANDMETASTASISOFCHOLANGIOCARCINOM
3、AChenboDepartmentofGeneralSurgery,ninthPeople'sHospitalofChongqing[Abstract]Objective:TodiscussetheroleofRHAMMininvasionandmetastasisofcholangiocarcinoma.Methods:Collectingclinicalspecimensofnormalbileductandcholangiocarcinomainpatients.AccordingtotheTNMstagingsystem,wed
4、ividedthespecimentsintothreegroups.TheexpressionsofRHAMMproteinlevelwereassayedbyImmunohistochemistryandWesternblot.Results:TherearedifferentexpressionlevelsindifferenthistologicaltypesofcholangiocarcinomaassayedbyImmunohistochemistry(P>0.05).CholangiocarcinomagroupandCh
5、olangiocarcinomawithmetastasisgrouphadpositiveexpressionofRHAMMwithstainedbrowninthecytoplasmormembrane.TheexpressionlevelofRHAMMwaslowestinthecontrolgroup(0.033±0.003),whileincreasedinthecholangiocacinomagroup(0.162±0.013).Therewerenosignificantdifferencebetweenthetwogr
6、oups(P>0.05).Thecholangiocarcinomawithmetastasisgroupholdsignificantlyhigherexpressionthantheothertwogroups,andthedifferencehadstatisticalsignificance(P<0.05).Conclusion:TherewerenorelationsbetweenthepathologicaltypesofcholangiocarcinomaandtheexpressionlevelsofRHAMM.Howe
7、ver,itshighexpressioninthecholangiocarcinomawithmetastasisgroupmayassociatewiththeinvasionofcholangiocarcinoma,andpromotethetransferofcholangiocarcinomaultimately.[Keywords]:Haluronicacid;Rceptorforhyaluronan-mediatedmotility;cholangiocarcinoma;invasion;metastasis 提供更好的
8、翻译建议胆管癌(cholangiocarcinoma)是一种来源于肝内或肝外胆管上皮的肿瘤,其发病率仅次于肝癌。其发展隐蔽,临床症状及体征出现晚,恶性程度高。神经侵犯和周围纤维组织侵犯是胆管癌转移的重要特点
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