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1、·精元康胶囊对骨髓抑制小鼠造血功能及凋亡相关蛋白的影响达、下调Bax蛋白的表达,优于利可君组和模型组(P<0.05);精元康胶囊低剂量组在上调骨髓有核细胞Bcl-2蛋白表达、下调Bax蛋白表达方面也有一定效果。结论:精元康胶囊能有效地改善CTX致骨髓抑制小鼠的骨髓功能,其作用机制可能为:①精元康胶囊具有显著提高外周血白细胞、红细胞、血红蛋白和血小板的作用,尤其在提高外周血白细胞和血小板方面作用明显;②精元康胶囊具有显著提升骨髓有核细胞数的作用;③精元康胶囊在上调Bcl-2蛋白表达的同时,下调Bax蛋白表达,使Bcl-2/Bax比值增大,防止骨髓造血细胞凋亡。本实验
2、结果表明,精元康胶囊具有抗骨髓细胞凋亡作用,这可能是在骨髓抑制状态下,精元康胶囊促进骨髓细胞增殖和骨髓造血功能恢复的机制之一。关键词:小鼠;骨髓抑制;环磷酰胺;精元康胶囊;利可君片;骨髓有核细胞数;凋亡相关蛋白···-2-···AbstractEffectofJingyuankangCapsuleonHematopoieticFunctionandApoptosis-associatedProteinsofMyelosuppressedMiceWangHongling(InternalMedicineofTCM)Directedby:ProfessorJiangS
3、hiqingAbstractObjective:ToobservetheeffectofJingyuankangCapsuleonleucocyte,erythrocyte,hemoglobin,platelet,bonemarrowcellandapoptosis-associatedproteinsonmyelosuppresseofmiceinducedbycyclophosphamide(CTX),andtofindoutthemechanismofJingyuankangCapsuleinamelioratingthehematopoieticfunct
4、ionofmyelosuppressedmice,whichwouldprovidetheexperimentalevidenceforclinicapplication.Methods:Select144KMmice(male,6~8weeksage,18~22gweight),whichwererandomlydividedinto6groups(normalgroup,modelgroup,Likejuntabletgroup,JingyuankangCapsulehigh-dosegroup,JingyuankangCapsulemedium-dosegr
5、oup,JingyuankangCapsulelow-dosegroup),24miceineachgroup.Between1~3rddayeverymorning,eachgroupwasadministratedbygastricperfusionofCTXinjection100mg/kg(normalgroupwasinjected0.9%NSbyabdominalcavity.);Between1~9thdayeveryafternoon,normalgroupandmodelgroupwereadministratedbygastricperfusi
6、onof0.5%CMC-Na,LikejunTabletgroupwastreatedwithLikejunTablet32mg/20ml/kg,JingyuankangCapsulehigh-dosegroupwithJingyuankangCapsule4g/20ml/kg,JingyuankangCapsulemedium-dosegroupwithJingyuankangCapsule3g/20ml/kg,JingyuankangCapsulelow-dosegroupwithJingyuankangCapsule2g/20ml/kg.Between1~1
7、0thdayeverymorning,randomlyselect8micefromeachgroup,cuttheirtailsinturntoobtain20μlbloodeach,dripintotesttubesofEDTA-K2dilutiontobeusedforinspectinghemogramandprintingdatabyautomaticbloodcellanalysator.Onthe5th,7th,10thday,select8micerandomlyfromeachgroupforexecution,takeoutthebonemar
8、rowce