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1、LithiumasaProtectiveFactoragainstDementiainBipolarPatients—ARetrospe…LithiumasaProtectiveFactoragainstDementiainBipolarPatients—ARetrospectiveCohortStudyDianaPaleacuKertesz1,2*,MeirDvir2,ShellyTadjer3,AsafShellef2,31NeurologyServiceandMemoryClinic,AbarbanelMentalHealthCenter,BatYam,Is
2、rael2SacklerSchoolofMedicine,TelAvivUniversity,TelAviv,Israel3DepartmentofPsychiatry,AbarbanelMentalHealthCenter,BatYam,IsraelAbstractBackground:Controversialresearchhasindicatedpotentialneuroprotectivequalitiesoflithiuminthepreventionofdementia,butitdidnotleadtoadefiniteconclusion.Ai
3、m:ethods:Ofaretrospectivecohortincluding433patientfilesthatmetinclusioncriteria(ageover65yearsandbipolardiseasecodedbyICD),147filescontainedenoughrelevantdata.Thepatients’filesusers(LU)forthoseforatleastaminimumof3monthsandnon-users(LNU)forthoseatalloruseditforaperiodoflessthan3months
4、.ethodsThisisaretrospectivecohortthearchives(puterizedandpaperfiles)oftheAbarbanelMentalHealthCenter,TheYaffoMentalHealthClinicandthePetahTiqvaMentalHealthClinic(bothadjoinedtothehospital).Thefilesincludedaperiodof10years(betber2013).Theyationaterialitselfinimizeexposureofpersonalpati
5、entinformation.Thestudyittee).2.1.InclusionandExclusionCriteriaIVcriteria.MMSEtestsostofthefiles,andthusnotincludedintheresearcheither.enonly.LithiumnonuserLithiumuserTotalNoDementia26(43.33%)*25(41.66%)*51(85%)Dementia7(11.66%)*2(3.33%)*9(15%)Total33(55%)27(45%)60(100%)*χ2(1)=2.220,p
6、>0.05.D.P.Kerteszetal.160Table3.LithiumandDementia,CI)andlocontinuoususe(12monthsintheresearch).s.HanaZemishlanyandMr.AlexeiSigalovforhelpingentoftheM.D.thesisrequirementsoftheSacklerFacultyofMedicine,TelAvivUniversity.FinancialandMaterialSupportMeirDvir,ShellyTadgerandAsafShelefha
7、venothingtodeclare.DianaPaleacuKerteszhasreceivedconsultingfees,lecturefeesfromNovartisandparticipatedinpaidadvisoryboardsforNovartisandSamuelovPharmaceuticals.Thisstudyhasnotbeenfunded.References[1]Smith,L.A.,Victoria,C.andoodStabilizersandAntipsychoticsintheMaintenancePhaseofBipolar
8、Disor
