资源描述：
《Protective behavior of tamoxifen against Hg(2 )-induced toxicity on kidney mitochondria In vitro and in vivo experiments》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、GModelSBMB36881–6ARTICLEINPRESSJournalofSteroidBiochemistry&MolecularBiologyxxx(2011)xxx–xxxContentslistsavailableatScienceDirectJournalofSteroidBiochemistryandMolecularBiologyjournalhomepage:www.elsevier.com/locate/jsbmbProtectivebehavioroftamoxifenagainstHg2+1-inducedt
2、oxicityonkidney2mitochondria:Invitroandinvivoexperiments3Q1LuzHernández-Esquivel,CeciliaZazueta,MabelBuelna-Chontal,SauriHernández-Reséndiz,∗4NataliaPavón,EdmundoChávez5DepartamentodeBioquímica,InstitutoNacionaldeCardiología,IgnacioChávez,Tlalpan,D.F.014080,Mexico67artic
3、leinfoabstract89Articlehistory:Heavymetalsareknowntoinducefunctionalalterationsinkidneymitochondria,thisdamageplaysacen-10Received1March2011tralroleinthemercury-inducedacuterenalfailure.Infact,mercurycausesrapidanddramaticchanges11Receivedinrevisedform12July2011inthe2+me
4、mbrane’sionicpermeabilityinsuchawaythatasupraloadofmitochondrialCaAcceptedoccurs.Asa1220July2011consequence,thephenomenonofpermeabilitytransitiontakesplace.Inthisworkwestudiedinvitroand13inKeywords:vivotheprotectiveeffectoftheselectiveestrogenreceptormodulatortamoxifenon
5、thedeleterious14actionTamoxifenofmercury-inducednonselectivepermeabilityinkidneymitochondria.Addedinvitrotamoxifen15inhibitedmembrane2+nonspecificporeopening,broughtaboutbyHgMercury,aswellastheoxidativedamage16toxicityof2+17Mitochondriatheenzymecis-aconitase.Invivotheadmi
6、nistrationoftamoxifenpreventedHg-inducedpoison-Permeabilityingonmitochondrialenergy-dependentfunctions.Permeabilitytransitionwasanalyzedbymeasuring18transition2+matrix19CalciumCaretention,mitochondrialswelling,andthebuildupandmaintenanceofatransmembraneelectricgradient.T
7、hepharmacologicactionoftamoxifenonmercurypoisoningcouldbeascribedtoitscyclosporin-likeaction.©2011ElsevierLtd.Allrightsreserved.201.Introductionmoleculeshavebeenproposedtoactaspossiblepore,i.e.,theade-39ninenucleotidecarrier[11–13]andthephosphatecarrier[14,15].4021Mercur
8、ybringsaboutacuterenalfailurethroughitsinteractionInhibitionofporeopeningcanbeachievedbyadifferentsort4
