结直肠癌相关pirnas的筛选及其对结直肠癌干细胞样特性的调控及机制研究

《结直肠癌相关pirnas的筛选及其对结直肠癌干细胞样特性的调控及机制研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、授予单位代码10089学号或申请号20151036中国图书分类号R735.3HebeiMedicalUniversity博士学位论文学术学位结直肠癌相关piRNAs的筛选及其对结直肠癌干细胞样特性的调控及机制研究研究生：尹洁导师：姜慧卿教授专业：内科学二级学院：第二医院2018年4月目录中文摘要··············································································1英文摘要··························

2、····················································4英文缩写··············································································8研究论文结直肠癌相关piRNAs的筛选及其对结直肠癌干细胞样特性的调控及机制研究引言·············································································10

3、第一部分结直肠癌相关piRNAs的筛选前言·············································································12材料与方法····································································13结果·············································································19附

4、图·············································································22附表·············································································27讨论·············································································34小结·············

5、································································36参考文献·······································································36第二部分结直肠癌相关piR-19521增加结直肠癌干细胞样特性前言·············································································41材料

6、与方法····································································42结果·············································································58附图·············································································66附表····················

7、·························································91讨论·············································································94小结·············································································96参考文献································

8、·······································97第三部分piR-19521通过促进ALX4表达增加结直肠癌干细胞样特性前言···········································································101材料与方法········································