卵巢癌化疗耐药机制的研究进展

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1、授予单位代码10089学号或申请号20153427中国图书分类号R711.75HebeiMedicalUniversity硕士学位论文专业学位卵巢癌化疗耐药机制的研究进展研究生：赵江静导师：张辉教授专业：妇产科学二级学院：第四医院2018年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据

2、、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。研究生签名：导师签章：二级学院领导盖章：年月日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：导师签章：年月日目录中文摘要··················································································

3、··························1英文摘要············································································································2英文缩写············································································································3综述卵巢癌化疗耐药机制的研究进展·

4、·······················································4致谢··················································································································20个人简历····························································································

5、··············21中文摘要卵巢癌化疗耐药机制的研究进展摘要卵巢癌是当今全世界最致命的妇科恶性肿瘤[1]，目前标准的治疗方案是手术结合以铂类为基础的药物化疗，复发及耐药是卵巢癌治疗失败的关键。化疗耐药是多水平、多因素、多基因一起参与的过程。其不仅是当前研究的热门，亦是卵巢癌治疗突破的关键。以往研究已证实细胞内有效药物浓度的减少、DNA损伤修复异常、细胞凋亡途径的抑制与卵巢癌化疗耐药相关。近些年的研究表明免疫逃逸、肿瘤微环境、非编码RNA、自噬相关等因素亦参与卵巢癌化疗耐药。探索卵巢癌细胞耐药相关机制、降低卵巢癌耐药、增加化

6、疗敏感性以及寻找有效逆转耐药的作用靶点，发明创新性药物势在必行。关键词：卵巢癌，化疗耐药，机制，凋亡，免疫逃逸，微环境，自噬1英文摘要AdvancesinResearchofChemotherapyResistanceMechanisminOvarianCancerABSTRACTOvariancanceristhemostdeadlygynecologicmalignancyintheworldtoday[1].Atpresent,thestandardtreatmentplanissurgerycombinedwithplatin

7、um-basedchemotherapy,butrelapseanddrugresistancearethekeytotreatmentfailureofovariancancer.Chemotherapyresistanceisaprocessinwhichmultiplelevels,multiplefactors,andmultiplegenesareinvolved.Chemotherapyresistanceisnotonlythecurrentresearchhotspot,butalsothekeytothebreakt

8、hroughofovariancancertreatment.Previousstudieshavedemonstratedthatthereductionofeffectivedrugconcentrationince