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1、1311治疗甲亢后早发甲低50例临床研宄孙小力(辽宁省盖州市中心医院115200}【摘要】目的探讨和分析采用1311治疗甲亢患者后继发早发甲低的临床因素。方法回顾性分析木院2011年03月至2013年03月木院收治的釆用1311治疗甲亢患者临床资料,治疗后定期随访,根据是否继发甲低将患者分成甲低组与非甲低组,通过统计学处理分析两组患者在年龄、性别、病程、治疗前甲状腺质量、1311剂量、治疗前后甲状腺功能、计划给予每克甲状腺组织的摄取剂量、是否接受过内科药物治疗等因素与甲低的关系。结果随访1年后,23.15%(50/216)患者治疗后继发甲低,76.85%(1
2、66/216)患者甲状腺恢复正常,两组患者在1311剂量上无显著性差异(P>0.05),但两组患者在每克组织给予的摄取剂量间差异存在显著性差异(P<0.05)。结论临床研究结果表明采用1311治疗甲亢时继发甲低与患者每克组织摄取的1311量密切相关,临床上可以通过适当调整1311的给药量来减少和避免早发甲低的发生。【关键词】1311甲状腺功能亢进甲状腺功能减退临床疗效【中图分类号】R45【文献标识码】A【文章编号】1672-5085(2014)26-0126-02【Abstract】ObjectiveToinvestigateandanalysi
3、stheclinicalfactorsinpatientswithsecondaryhypothyroidismafter1311therapyforhyperthyroidism.Methodsaretrospectiveanalysisofourhospitalin201103to201303monthsinthehospitalclinicaldataof1311treatmentforhyperthyroidism,regularfollow-upaftertreatment,accordingtowhetherthepatientsweredivi
4、dedintosecondaryhypothyroidismhypothyroidismgroupandnonhypothyroidismgroup,throughstatisticalanalysisoftwogroupsinage,sex,courseofdisease,beforeandafterthetreatmentofthyroidmass,1311dose,treatmentofthyroidfunction,plantogivetheingestiondosepergramofthyroidtissue,whethertherelations
5、hipbetweendrugtreatmentreceivedDepartmentofinternalmedicineandfactorssuchashypothyroidism.After1yearsoffollow-upresults,23.15%(50/216)subsequenthypothyroidismpatients,76.85%(166/216)inpatientswiththyroidreturnedtonormal,thetwogroupshadnosignificantdifferencein1311dose(P>0.05),bu
6、ttherewassignificantdifferencebetweentwogroupsofpatientstreatedintheabsorptiondosepergramoftissue(P<0.05).Conclusiontheclinicalresearchresultsshowthatthe1311treatmentofhyperthyroidismiscloselyrelatedto1311andsecondaryhypothyroidismpatientspergramoftissueuptakeby,clinicaloncanbya
7、djustingthedosageof1311toreduceandavoidtheoccurrenceofearlyhypothyroidismo【Keywords]1311hyperthyroidismhypothyroidismclinicalcurativeeffect甲状腺功能亢进症(hyperthyroidism,简称甲亢)是指患者甲状腺腺体本身产生甲状腺激素功能增强,导致甲状腺激素积累过多而引起的甲状腺毒症。毒性弥漫性甲状腺肿(Graves病)是甲亢中最常见的疾病之一,约山*全部甲亢患者的80-85%[1]。目前Graves病的仍以药物治疗为主
8、,临床研究表明,采用1311治疗甲亢患者后容易继发甲