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ID:17456474
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页数:4页
时间:2018-09-01
《产前和产后联合阻断 HBsAg 阳性孕妇母婴传播的研究.doc》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、产前和产后联合阻断HBsAg阳性孕妇母婴传播的研究【摘要】目的评价产前和产后联合阻断措施,对乙型肝炎表面抗原(HBsAg)阳性孕妇母婴传播的阻断效果。方法将乙型肝炎表面抗原(HBsAg)阳性的孕妇在产前检查时随机分为两组,人乙型肝炎免疫球蛋白(HBIG)组:HBsAg、HBeAg双阳性组孕妇产前4个月(妊娠24周起)每4周肌肉注射HBIG200IU直至临产;HBsAg单阳组孕妇产前3个月(妊娠28周起)每4周肌肉注射HBIG200IU直至临产;对照组孕妇不注射HBIG。两组所生新生儿于出生后2h内及2个月取股静脉血,检测乙型
2、肝炎病毒感染标志HBVM。双阳性组母亲分娩新生儿每10天肌肉注射HBIG200IU,单阳组母亲分娩新生儿每15天肌肉注射HBIG200IU。结果HBIG组母亲所生新生儿宫内感染率为2.6%,2个月时具有保护性抗体有效保护率为95.6%;对照组母亲所生新生儿宫内感染率为39.3%,2个月时具有保护性抗体的有效保护率为76.4%,宫内感染率比较χ2=3.86,P<0.05。结论产前和产后联合阻断乙型肝炎病毒的母婴传播有效保护率达到95.6%,能明显减少宫内感染的发生,获得目前最大限度的提高对乙型肝炎病毒母婴传播的阻断作用。
3、【关键词】乙型肝炎病毒母婴阻断人乙型肝炎免疫球蛋白垂直传播.【Abstract】ObjectiveToevaluatetheeffectofcombiningantepartumwithpostpartumtobreakuptransmissionofHBV.MethodsHBVcarriermother,whoseHBsAgpositive,andlatertheirinfantswererandomlydividedintotwogroups.Thegravidsingroup-1,whoseHBsAgandHBeAgw
4、erebothpositive,received200IUHBIGevery-four-week(frompregnancyfor24weektodelivery).Thegravidsingroup-1,whoseonlyHBsAgwaspositive,received200IUHBIGevery-four-week(frompregnancyfor28;weektodelivery).Thegravidsingroup-2didnotreceivedHBIG(thecontrolgroup).Afterdelivery
5、,alltheinfantsinbothgroupsobtainedserafromfemoralveintotestHBVmarkers,intwohoursandattwomonths.TheinfantsofmotherwhoseHBsAgandHBeAgwerepositive,received200IUHBIGevery-ten-day.TheinfantsofmotherwhoseonlyHBsAgwaspositive,received200IUHBIGevery-fifteen-day.ResultsIngr
6、oup-1,therateofintrauterineHBVinfectionwas2.6%,andattwo-month-old,therateofinfantswiththeprotectivelevelagainstHBVinfectionwas95.6%.Ingroup-2,therateofintrauterineHBVinfectionwas30.3%,andattwo-month-old,therateofinfantswiththeprotectivelevelagainstHBVinfectionwas76
7、.4%.χ2-testwasusedtocomparethedifferentratesofintrauterineHBVinfectionbetweenthetwogroups.(χ2=3.86P<0.05).ConclusionMorethan95.6%high-riskinfants,whowereborntoHBsAg-positivecarriermother,wereprotectedbytheantepartumwithpostpartumofimmunoprophylaxis,whichcansigni
8、ficantlyinterruptthe4transmissionofHBVfrommotherswithpositiveHBsAgtotheirinfants.【Keywords】hepatitisBvirusinterruptionofmaternal-infantiletransmi
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