医药学临床医学毕业论文 产前和产后联合阻断 hbsag 阳性孕妇母婴传播的研究

《医药学临床医学毕业论文 产前和产后联合阻断 hbsag 阳性孕妇母婴传播的研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、湖南师范大学本科毕业论文考籍号：XXXXXXXXX姓名：XXX专业：医药学临床医学论文题目：产前和产后联合阻断HBsAg阳性孕妇母婴传播的研究指导老师：XXX二〇一一年十二月十日【摘要】目的评价产前和产后联合阻断措施，对乙型肝炎表面抗原（HBsAg）阳性孕妇母婴传播的阻断效果。方法将乙型肝炎表面抗原（HBsAg）阳性的孕妇在产前检查时随机分为两组，人乙型肝炎免疫球蛋白（HBIG）组：HBsAg、HBeAg双阳性组孕妇产前4个月（妊娠24周起）每4周肌肉注射HBIG200IU直至临产；HBsAg单阳组孕妇产前3个月（妊娠28周起）每4周肌肉注射HBIG200IU直至临产；对照

2、组孕妇不注射HBIG。两组所生新生儿于出生后2h内及2个月取股静脉血，检测乙型肝炎病毒感染标志HBVM。双阳性组母亲分娩新生儿每10天肌肉注射HBIG200IU，单阳组母亲分娩新生儿每15天肌肉注射HBIG200IU。结果HBIG组母亲所生新生儿宫内感染率为2.6%，2个月时具有保护性抗体有效保护率为95.6%；对照组母亲所生新生儿宫内感染率为39.3%，2个月时具有保护性抗体的有效保护率为76.4%，宫内感染率比较χ2=3.86，P0.05。结论产前和产后联合阻断乙型肝炎病毒的母婴传播有效保护率达到95.6%，能明显减少宫内感染的发生，获得目前最大限度的提高对乙型肝炎病毒

3、母婴传播的阻断作用。【关键词】乙型肝炎病毒母婴阻断人乙型肝炎免疫球蛋白垂直传播.【Abstract】ObjectiveToevaluatetheeffectofcombiningantepartumwithpostpartumtobreakuptransmissionofHBV.MethodsHBVcarriermother，whoseHBsAgpositive，andlatertheirinfantswererandomlydividedintotwogroups.Thegravidsingroup-1，whoseHBsAgandHBeAgwerebothpositive

4、，received200IUHBIGevery-four-week(frompregnancyfor24weektodelivery).Thegravidsingroup-1，whoseonlyHBsAgwaspositive，received200IUHBIGevery-four-week(frompregnancyfor28；weektodelivery).Thegravidsingroup-2didnotreceivedHBIG(thecontrolgroup).Afterdelivery，alltheinfantsinbothgroupsobtainedserafr

5、omfemoralveintotestHBVmarkers，intwohoursandattwomonths.TheinfantsofmotherwhoseHBsAgandHBeAgwerepositive，received200IUHBIGevery-ten-day.TheinfantsofmotherwhoseonlyHBsAgwaspositive，received200IUHBIGevery-fifteen-day.ResultsIngroup-1，therateofintrauterineHBVinfectionwas2.6%，andattwo-month-old

6、，therateofinfantswiththeprotectivelevelagainstHBVinfectionwas95.6%.Ingroup-2，therateofintrauterineHBVinfectionwas30.3%，andattwo-month-old，therateofinfantswiththeprotectivelevelagainstHBVinfectionwas76.4%.χ2-testwasusedtocomparethedifferentratesofintrauterineHBVinfectionbetweenthetwogroups.

7、(χ2=3.86P0.05).ConclusionMorethan95.6%high-riskinfants，whowereborntoHBsAg-positivecarriermother，wereprotectedbytheantepartumwithpostpartumofimmunoprophylaxis，whichcansignificantlyinterruptthetransmissionofHBVfrommotherswithpositiveHBsAgtotheirinfants.【Keywords