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1、膳食干预肠道菌群预防代谢性疾病DietaryModulationofGutMicrobiotaforPreventivemanagementofMetabolicDiseases赵立平LipingZhao上海交通大学生命科学技术学院上海系统生物医学研究中心ShanghaiJiaoTongUniversityHumanSuperorganisms正确认识自己的身体－“超级生物体”诺贝尔奖得主-里德伯格,Science2000JoshuaLederbergNobelLaureate1958人体内生活着1-2公斤细菌90%在肠道里人体的细胞组成10%人细胞+90%细菌细胞人体的基因组成2
2、.5万个人的基因3百多万个微生物基因丰富而活跃的代谢活动肠道菌群——人体后天获得的“第二个基因组”GutMicrobiota-Secondgenomeacquiredafterbirth食品药品人基因组肠道微生物组健康疾病体质亚健康先天遗传后天养成“慢性病的肠道起源” “人体系统生物学方法”慢性病的肠道起源GutOriginofChronicDiseasesIIyaMechnikovNobelLaureate1908“Laterhetookupthestudyofthefloraofthehumanintestineanddevelopedatheorythatsenilityis
3、duetopoisoningofthebodybytheproductsofcertainofthesebacteria.Topreventthemultiplicationoftheseorganismsheproposedadietcontainingmilkfermentedbybacilliwhichproducelargeamountsoflacticacidandforatimethisdietbecamewidelypopular.”-http://nobelprize.org/Symbiosisvs.Dysbiosis“粪毒入血，百病蜂起”——中医观念“Fecalt
4、oxinsintobloodstreamwillleadtoallkindsofdiseases”——ConceptfromTraditionalChineseMedicine(TCM)细胞毒素、遗传毒素、免疫毒素-肝肠循环-肠屏障受损肠道菌群结构失调与代谢综合征Cani,2009肠道菌群控制能量代谢基因表达Backhed,F.,etal.,Thegutmicrobiotaasanenvironmentalfactorthatregulatesfatstorage.ProcNatlAcadSciUSA,2004.101:15718-15723.Backhed,F.,etal.,Me
5、chanismsunderlyingtheresistancetodiet-inducedobesityingerm-freemice.ProcNatlAcadSciUSA,2007.104:979-984.Turnbaugh,P.J.,etal.,Anobesity-associatedgutmicrobiomewithincreasedcapacityforenergyharvest.Nature,2006.444(7122):p.1027-1031.Turnbaugh,P.J.,etal.,Diet-inducedobesityislinkedtomarkedbutrever
6、siblealterationsinthemousedistalgutmicrobiome.CellHostMicrobe,2008.3:213-223.JefferyGordon肥胖糖尿病炎性衰老低度、系统性的慢性炎症慢性炎症与衰老和老年病的关系InflammationandAge-relatedDiseases代谢性疾病Endotoxin-themostcommonimmunotoxin内毒素-最常见的免疫毒素内毒素MolecularInflammationinducedbyendotoxin内毒素诱导的分子炎症Inflammationinducedbydiet-disrupt
7、edgutmicrobiota菌群结构失调诱发慢性炎症Cani,P.D.,Amar,J.,Iglesias,M.A.,Poggi,M.,Knauf,C.,Bastelica,D.etal.(2007a)Metabolicendotoxemiainitiatesobesityandinsulinresistance.Diabetes56:1761-1772.Cani,P.D.,Neyrinck,A.M.,Fava,F.,Knauf,C.,Burcelin,R.G.,Tu
