泌尿内科医学论文范文

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1、慢性肾功能不全患者血栓调节蛋白与心脑血管并发症关系的探讨　　作者：李忠心，陈向东作者单位：100020北京，首都医科大学附属北京朝阳医院肾内科　　【摘要】目的探讨慢性肾功能不全患者血栓调节蛋白(Tm)与心脑血管并发症的关系。方法北京朝阳医院肾内科2005～2006年期间住院的86例慢性肾脏病患者，按照CKD分期标准划分为肾功能正常组(GFR≥90ml/min)42例和肾功能不全组(GFR<89ml/min)44例。合并心、脑血管疾病的诊断均根据其临床表现、生化指标和冠脉造影或CT、MRI等影像学改变。清晨空腹采静脉血分别测定血肌酐、胆固醇、甘油三酯、

2、高密度脂蛋白、低密度脂蛋白及血栓调节蛋白。结果慢性肾脏病肾功能不全组Tm水平明显高于肾功能正常组和对照组(P<005)，伴心脑血管并发症患者Tm水平较不伴并发症患者明显升高(P<005)。将86例患者作为一个整体，进行多元逐步回归分析，结果显示：血栓调节蛋白、低密度脂蛋白、收缩压和血肌酐分别与慢性肾脏病合并心脑血管并发症密切相关。结论慢性肾脏病功能不全患者血栓调节蛋白升高，血栓调节蛋白与慢性肾脏病合并心脑血管并发症密切相关。　　【关键词】慢性肾脏病;慢性肾功能不全;血栓调节蛋白　　Relationshipbetweenthrombomodulin

3、andcardio-cerebrovascularcomplicationsinpatientswithchronicrenalfailure　　LIZhong-xin，CHENXiang-dong.DepartmentofNephrology，ChaoyangHospitalofCapitalMedicalUniversity，Beijing100020，China　　[Abstract]ObjectiveTodeterminetherelationshipbetweenthrombomodulinandcardio-cerebrovascular

4、complicationsinpatientswithchronicrenalfailure.MethodsEighty-sixchronickidneydiseases(CKD)patientsfromDepartmentofNephrology，ChaoyangHospital.and60healthyvolunteerswereincludedinthisstudy.Eighty-sixCKDpatientsweredividedintorenalfailuregroupandnormalrenalfunctiongroupaccrodingt

5、oCKDstagingstandard.Diagnosisofcardio-cerebrovascularcomplicationswasonthebasisofclinicalmanifestation，biochemicalindicator，coronaryarteringraphy，CT，MRI，etal.Bloodwasdrawnafteranovernightfast.BloodlevelsofthrombomodulinweremeasuredusingELISAmethod.Therewerealsobloodtesttomeasur

6、ecreatinine(Scr)，triglycerides(TG)，cholesterol(ChoL)，low-densitylipoproteincholesterol(LDL)，high-densitylipoproteincholesterol(HDL).ResultsThemeanlevelofTmwashigherinchronicrenalfailurepatientsthanthatinnormalrenalfunctionpatientsandinthehealthycontrols(P<005).ThemeanlevelofTm

7、wassignificantlyhigherinchronicrenalfailurepatientswithcardio-cerebrovascularcomplicationsthanthatinpatientswithoutcardio-cerebrovascularcomplications(P<005).MultivariatestepwiseregressionanalysisshowedthatinCRFpatients，thecorrelationassociatedwithcardio-cerebrovascularcomplic

8、ationswereTm，LDL，SBP，Scr.ConclusionSerumthrombomodulin