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1、经尿道电切综合征模型的建立和心功能评价来源：医学论文发表——创新医学网http://www.yixue360.com/　　作者：冯艳红作者单位：辽宁医学院附属第一医院泌尿外科，辽宁锦州121001　　【摘要】目的以5%甘露醇冲洗液建立犬经尿道电切综合征(TURS)模型，探讨TURS对心功能影响。方法家犬8只，以100mL/min速度静脉输入5%甘露醇冲洗液3000mL，建立犬TURS模型;于输液前和输液后10、20、30、60min，测定心功能，血清钾、钠、氯浓度，心肌酶谱，心电图，并进行病理观察。结果心率、左室舒张期末内径、收

2、缩期末内径在30min时增加(P值均<0.05)，收缩压、舒张压、脉压和射血分数30min时降低(P值均<0.05)。血清天冬氨酸转氨酶、乳酸脱氢酶、肌酸激酶和肌酸激酶同工酶在60min时的变化无统计学意义(P>0.05)。TURS时心电图可有心律不齐和心肌缺血改变。病理观察示心肌纤维间充血和局部变性，肺脏水肿。结论TURS可引起心功能改变，并造成心肌损伤。发生TURS时心率和血压的改变出现较早，应足够重视，并及时的检测血清离子。　　【关键词】经尿道电切综合征水中毒心功能心肌酶谱犬　　EstablishmentoftheTran

3、surethralProstateResectionSyndromeModelandtheEvaluationonCardiacFunction医学论文发表——创新医学网http://www.yixue360.com/　　FENGYanhong，JIANGHuamao，ZHANGChunyang，ZHANGDatian，LIUYan　　DepartmentofUltrasound,theFirstAffiliatedHospitalofLiaoningMedicalUniversity，Jinzhou121001China　　A

4、bstract:ObjectiveToestablishthetransurethralprostateresectionsyndromemodelindogsandprobeintotheeffectsoncardiacfunctionofthemodelsofTURS.MethodsWeestablishedanimalmodelsineightdogsbyintravenousinjectionsof3000mL5%Mannitolat100mL/min.Cardiacfunctionandelectrocardiogra

5、mwereexaminedbeforeandafter10,20,30and60minuteswhenserumdielectrics,myocardialenzymesweremeasured.Samplesofthecardiacmuscleandlungweretakenout60minutesafterthedrugadministrationandwereobservedthehistologicalchanges.ResultsHeartrate,leftventricularend-diastolicdimensi

6、onandleftventricularend-systolicdimensionwereincreased30minutesafteradministration(P<0.05),systolicbloodpressure,diastolicbloodpressurepulsepressureandejectionfractionandshorteningfractionbutdecreasedin30minutes(P<0.01).Theserumsodium,potassiumandchloridelevelswerede

7、creasedatanytimepoints,butthechangesofmyocardialenzymeswereinsignificantlyin60minutesafter医学论文发表——创新医学网http://www.yixue360.com/administration(P>0.05).Thereweresuchchangesasanisorhythmia,myocardialischemiainelectrocardiogram.Pathologicalexaminationrevealedhyperaemiaam

8、ongmyocardialfiberscardiacmusclefibers,partapomorphosisandedemaoflung.ConclusionsTURSmaycausechangesoncardiacfunctionandmyocardiald