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1、经尿道电切综合征模型的建立和心功能评价来源：医学论文发表——赛恩斯作者：冯艳红作者单位：辽宁医学院附属第一医院泌尿外科,辽宁锦州121001【摘要】目的以5%廿露醇冲洗液建立犬经尿道电切综合征(TURS)模型，探讨TURS对心功能彩响。方法家犬8只，以100mL/min速度静脉输入5%甘露醇冲洗液3000mL,建立犬TURS模型;于输液前和输液后10、20、30、60min,测定心功能，血清钾、钠、氯浓度，心肌酶谱，心电图，并进行病理观察。结杲心率、左室舒张期末内径、收缩期末内径在30min时增加(P值均＜0.05),收缩压、舒张压、脉压和射血分数30min时降低(P值均＜0.05
2、)o血清天冬氨酸转氨酶、乳酸脱氢酶、肌酸激酶和肌酸激酶同工酶在60min时Jiffjiff的变化无统计学意义(P＞0.05)oTURS时心电图可有心律不齐和心肌缺血改变。病理观察示心肌纤维间充血和局部变性，肺脏水肿。结论TURS可引起心功能改变，并造成心肌损伤。发生TURS时心率和血压的改变出现较早，应足够重视，并及时的检测血清离子。【关键词】经尿道电切综合征水中毒心功能心肌酶谱犬EstablishmentoftheTransurethralProstateResectionSyndromeModelandtheEvaluationonCardiacFunctionFENGYanh
3、ong,JIANGHuamao,ZHANGChunyang,ZHANGDatian,LIUYanDepartmentofUltrasound,theFirstAffiliatedHospitalofLiaoningMedicalUniversity,Jinzhou121001ChinaAbstract:ObjectiveToestablishthetransurethralprostateresectionsyndromemodelindogsandprobeintotheeffectsoncardiacfunctionofthemodelsofTURS・MethodsWeesta
4、blishedanimalmodelsineightdogsbyintravenousinjectionsof3000mL5%Mannitolat100mL/min.Cardiacfunctionandelectrocardiogramwereexaminedbeforeandafter10,20,30and60minuteswhenserumdielectrics,myocardialenzymesweremeasured・Samplesofthecardiacmuscleandlungweretakenout60minutesafterthedrugadministration
5、andwereobservedthehistologicalchanges・ResultsHeartrate,leftventricularend-diastolicdimensionandleftventricularend-systolicdimensionwereincreased30minutesafteradministration(P<0.05),systolicbloodpressure,diastolicbloodpressurepulsepressureandejectionfractionandshorteningfractionbutdecreasedin30
6、minutes(P<0.01).Theserumsodium,potassiumandchloridelevelsweredecreasedatanytimepoints,butthechangesofmyocardialenzymeswereinsignificantlyin60minutesafteradministration(P>0.05).Thereweresuchchangesasanisorhythmia,myocardialischemiainelectrocardiogram.Pathologicalexaminationrevealedhyperaemiaamo
7、ngmyocardialfiberscardiacmusclefibers,partapomorphosisandedemaoflung.ConclusionsTURSmaycausechangesoncardiacfunctionandmyocardialdamage・ItwasearliertochangeheartrateandbloodpressurewhenTURShappened・Itisessentialtoexamineblooddielectrici
