欢迎来到天天文库
浏览记录
ID:17386614
大小:64.50 KB
页数:9页
时间:2018-08-30
《泌尿内科医学论文范文》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、慢性肾功能不全患者血栓调节蛋白与心脑血管并发症关系的探讨 作者:李忠心,陈向东作者单位:100020北京,首都医科大学附属北京朝阳医院肾内科 【摘要】目的探讨慢性肾功能不全患者血栓调节蛋白(Tm)与心脑血管并发症的关系。方法北京朝阳医院肾内科2005~2006年期间住院的86例慢性肾脏病患者,按照CKD分期标准划分为肾功能正常组(GFR≥90ml/min)42例和肾功能不全组(GFR<89ml/min)44例。合并心、脑血管疾病的诊断均根据其临床表现、生化指标和冠脉造影或CT、MRI等影像学改变。清晨空腹采静脉血分别测定血肌酐、胆固醇、甘油三酯、高密度脂蛋白、低密度脂
2、蛋白及血栓调节蛋白。结果慢性肾脏病肾功能不全组Tm水平明显高于肾功能正常组和对照组(P<005),伴心脑血管并发症患者Tm水平较不伴并发症患者明显升高(P<005)。将86例患者作为一个整体,进行多元逐步回归分析,结果显示:血栓调节蛋白、低密度脂蛋白、收缩压和血肌酐分别与慢性肾脏病合并心脑血管并发症密切相关。结论慢性肾脏病功能不全患者血栓调节蛋白升高,血栓调节蛋白与慢性肾脏病合并心脑血管并发症密切相关。 【关键词】慢性肾脏病;慢性肾功能不全;血栓调节蛋白 Relationshipbetweenthrombomodulinandcardio-cerebrovascu
3、larcomplicationsinpatientswithchronicrenalfailure LIZhong-xin,CHENXiang-dong.DepartmentofNephrology,ChaoyangHospitalofCapitalMedicalUniversity,Beijing100020,China [Abstract]ObjectiveTodeterminetherelationshipbetweenthrombomodulinandcardio-cerebrovascularcomplicationsinpatientswithchroni
4、crenalfailure.MethodsEighty-sixchronickidneydiseases(CKD)patientsfromDepartmentofNephrology,ChaoyangHospital.and60healthyvolunteerswereincludedinthisstudy.Eighty-sixCKDpatientsweredividedintorenalfailuregroupandnormalrenalfunctiongroupaccrodingtoCKDstagingstandard.Diagnosisofcardio-cerebr
5、ovascularcomplicationswasonthebasisofclinicalmanifestation,biochemicalindicator,coronaryarteringraphy,CT,MRI,etal.Bloodwasdrawnafteranovernightfast.BloodlevelsofthrombomodulinweremeasuredusingELISAmethod.Therewerealsobloodtesttomeasurecreatinine(Scr),triglycerides(TG),cholesterol(ChoL),lo
6、w-densitylipoproteincholesterol(LDL),high-densitylipoproteincholesterol(HDL).ResultsThemeanlevelofTmwashigherinchronicrenalfailurepatientsthanthatinnormalrenalfunctionpatientsandinthehealthycontrols(P<005).ThemeanlevelofTmwassignificantlyhigherinchronicrenalfailurepatientswithcardio-cere
7、brovascularcomplicationsthanthatinpatientswithoutcardio-cerebrovascularcomplications(P<005).MultivariatestepwiseregressionanalysisshowedthatinCRFpatients,thecorrelationassociatedwithcardio-cerebrovascularcomplicationswereTm,LDL,SBP,Scr.ConclusionSerumthrombomodulin
此文档下载收益归作者所有